Injectable Oxygen: Interfacing Materials Chemistry with Resuscitative Science
Injectable Oxygen: Interfacing Materials Chemistry with Resuscitative Science
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DOI：
10.1002/chem.201802054
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发表时间：
2018-12-17
影响因子：
4.3
通讯作者：
Polizzotti，Brian D.
中科院分区：
文献类型：
--
作者：
Peng，Yifeng;Kheir，John N.;Polizzotti，Brian D.
血管内氧输送在治疗包括肺部疾病、缺氧性肿瘤、失血性休克、中风、心脏骤停等多种缺氧性疾病和急症方面具有巨大的潜力。过去，人们做出了巨大的努力，为静脉输氧载体的发展找到了实质性的解决方案，从血液替代品到微气泡，都取得了有限的成功。本文重点介绍了全氟碳乳剂和微泡作为静脉气体载体的过去和最近的进展，包括对它们的长期稳定性、体内安全性和氧气传输效率的关注。文中还讨论了它们作为治疗各种类型心脏骤停的潜在复苏疗法的应用。
Intravascular oxygen delivery holds great potential to treat numerous hypoxic conditions and emergencies, including pulmonary disorders, hypoxic tumors, hemorrhagic shock, stroke, cardiac arrest and so on. Tremendous effort has been made in the past to find material solutions for the development of intravenous oxygen carriers and have ranged from blood substitutes to microbubbles with limited success. This paper highlights previous and recent progress in perfluorocarbon‐emulsions and microbubbles as intravenous gas carriers, including concerns over their long‐term stability, in vivo safety profiles, and oxygen transport efficacy. Their use as potential resuscitative therapeutics for treating various types of cardiac arrest is also discussed.