Efficient and regioselective synthesis of 5-hydroxy-2-isoxazolines: versatile synthons for isoxazoles, beta-lactams, and gamma-amino alcohols.
Efficient and regioselective synthesis of 5-hydroxy-2-isoxazolines: versatile synthons for isoxazoles, beta-lactams, and gamma-amino alcohols.
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DOI：
10.1021/jo1000065
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发表时间：
2010-02
期刊：
影响因子：
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通讯作者：
Shibing Tang;Jinmei He;Yongquan Sun;Liuer He;Xuegong She
中科院分区：
文献类型：
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作者：
Shibing Tang;Jinmei He;Yongquan Sun;Liuer He;Xuegong She
An efficient and highly regioselective protocol was developed for the preparation of 5-hydroxy-2-isoxazolines, which have been proved to be versatile synthons for isoxazles, beta-hydroxy oximes, and gamma-amino alcohols. Beta-lactams, commonly embedded in the skeletons of bioactive natural products, were also synthesized in two steps from beta-hydroxy oximes, providing a new strategy for the synthesis of this kind of compounds.
