New perspectives in epilepsy neuropathology.
New perspectives in epilepsy neuropathology.
复制标题
癫痫神经病理学的新观点。
DOI：
10.1111/nan.12464
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发表时间：
2018
影响因子：
5
通讯作者：
Thom,M
中科院分区：
文献类型：
--
作者：
Thom,M
随着20世纪50年代癫痫手术项目的开始，许多著名的神经病理学家抓住了这个机会，通过脑电图、神经成像、心理测量学以及切除所谓的“外来”脑组织后的结果，研究了各种病变。除了他们富有洞察力和细致的组织学描述之外，他们开始解决这些病变的原因，它们如何引起癫痫（“癫痫发生”过程）以及它们如何与癫痫相关的其他合并症或死亡率相关的问题。2018年，我们在这些基础上取得了进展，通过数十年经验积累的证据，更有信心切除手术是当前难治性局灶性癫痫患者的治疗选择。
As epilepsy surgery programmes commenced in the 1950s, many eminent neuropathologists embraced the opportunity to study the varied lesions identified in relation to electroencephalography, neuroimaging, psychometry as well as outcome following removal of what was termed the 'alien' brain tissue [1-3]. Beyond their insightful and meticulous histological descriptions, they began to address the questions of what caused these lesions, how they gave rise to epilepsy (the processes of 'epileptogensis') and how they related to other co-morbidities or mortality associated with epilepsy. Now in 2018 we have built on these foundations and, through the evidence amassed from decades of experience, there is greater confidence that resective surgery is a current treatment of choice in selected patients with refractory focal epilepsies.