Using exosomes, naturally-equipped nanocarriers, for drug delivery.
Using exosomes, naturally-equipped nanocarriers, for drug delivery.
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DOI：
10.1016/j.jconrel.2015.07.030
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发表时间：
2015-12-10
期刊：
影响因子：
--
通讯作者：
Kim MS
中科院分区：
文献类型：
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作者：
Batrakova EV;Kim MS
外泌体提供独特的优势，使其成为高效的药物载体。外泌体由细胞膜组成，在其表面上具有多种粘附蛋白，已知外泌体专门用于细胞-细胞通信，并提供将各种治疗剂递送至靶细胞的唯一方法。此外，外泌体可以通过其亲本细胞进行修饰以在其表面上表达靶向部分，或补充所需的生物活性。基于外泌体的药物递送系统的开发和验证是本文的重点。外泌体的分离，表征，药物负载，并在实验疾病模型和临床应用的不同技术进行了讨论。基于外来体的药物制剂可以应用于多种病症，例如癌症、各种感染性、心血管和神经退行性病症。总体而言，外泌体结合了合成纳米载体和细胞介导的药物递送系统的联合收割机益处，同时避免了它们的局限性。
Exosomes offer distinct advantages that uniquely position them as highly effective drug carriers. Comprised of cellular membranes with multiple adhesive proteins on their surface, exosomes are known to specialize in cell–cell communications and provide an exclusive approach for the delivery of various therapeutic agents to target cells. In addition, exosomes can be amended through their parental cells to express a targeting moiety on their surface, or supplemented with desired biological activity. Development and validation of exosome-based drug delivery systems are the focus of this review. Different techniques of exosome isolation, characterization, drug loading, and applications in experimental disease models and clinic are discussed. Exosome-based drug formulations may be applied to a wide variety of disorders such as cancer, various infectious, cardiovascular, and neuro-degenerative disorders. Overall, exosomes combine benefits of both synthetic nanocarriers and cell-mediated drug delivery systems while avoiding their limitations.