Handgrip strength among Nonagenarians and Centenarians in three European regions
Handgrip strength among Nonagenarians and Centenarians in three European regions
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DOI：
10.1093/gerona/61.7.707
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发表时间：
2006-07-01
影响因子：
5.1
通讯作者：
Robine, Jean-Marie
中科院分区：
文献类型：
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作者：
Jeune, Bernard;Skytthe, Axel;Robine, Jean-Marie
背景。握力是老年人残疾和死亡率的重要预测指标。研究的目的是比较欧洲三个地区老年人的握力。在欧洲健康老龄化挑战项目的这个子研究中，只有长寿的先证者被包括在内。选取三个握力测量值的最大值进行分析。对已知与握力相关的因素进行线性回归调整。在598名高龄老人（中位年龄= 98岁）中，观察到明显的南北梯度：男性的握力从丹麦南部的24.2 kg下降到法国朗格多克-鲁西永的20.8 kg，意大利卡拉布里亚的14.2 kg (p < 0.0001)，而女性的下降幅度较小（从12.2降至9.2 kg, p = 0.0021）。在调整了年龄、性别、住房、膝盖高度、日常生活活动（ADL）量表得分、六项迷你精神状态检查得分、椅子支架和年龄相关疾病的数量后，差异仍然显著，尽管这些因素解释了三分之二的握力差异。在欧洲三个不同地区的百岁老人和百岁老人中，我们发现双手握力的南北梯度显著，卡拉布里亚的数值明显较低。这一发现可能是由于人口背景差异（如遗传变异、出生体重、童年成长）和社会文化差异（如生活方式、卫生保健）。
Background. Handgrip strength is an important predictor of disability and mortality among old people. The aim was to compare the grip strength among very old people in three regions of Europe.Methods. In this substudy of the European Challenge for Healthy Aging project, only the long-lived probands were included. The maximum value of three measurements of handgrip strength was selected for the analysis. Adjustment for factors known to be correlated with grip strength was made by linear regression.Results. Among 598 very old people (median age = 98 years) a clear North-South gradient was observed: For men, handgrip strength dropped from 24.2 kg in Southern Denmark to 20.8 kg in Languedoc-Roussillon, France and 14.2 kg in Calabria, Italy (p < .0001), whereas for women the drop was smaller (from 12.2 to 9.2 kg; p = .0021). The difference remains significant after adjustment for age, gender, housing, knee height, Activities of Daily Living (ADL) scale score, score on the Six-Item Mini-Mental State Examination, chair stand, and number of age-related diseases, although these factors explain two thirds of the variation in handgrip strength.Conclusions. Among nonagenarians and centenarians in three different European regions, we found a significant North-South gradient in handgrip strength with substantially lower values in Calabria. This finding may be due both to population background differences (e.g., genetic variations, birth weight, childhood growth) and to sociocultural differences (e.g., lifestyle, health care).