The potential role of regulator of G-protein signaling 16 in cell motility mediated by δEF1 family proteins.
The potential role of regulator of G-protein signaling 16 in cell motility mediated by δEF1 family proteins.
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DOI：
10.1002/1873-3468.12042
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发表时间：
2016-01
期刊：
影响因子：
3.5
通讯作者：
Saitoh M
中科院分区：
文献类型：
--
作者：
Hoshi Y;Endo K;Shirakihara T;Fukagawa A;Miyazawa K;Saitoh M
上皮-间质转化（EMT）与肿瘤进展有关。我们之前报道了EMT的关键调控因子δEF1家族蛋白（δEF1/ZEB1和SIP1/ZEB2）的表达与EMT表型和乳腺癌的侵袭性呈正相关。本研究发现G蛋白信号传导调节因子16 （RGS16）的表达水平与δEF1家族蛋白的表达水平呈负相关。基于功能增益和功能损失分析的结果，我们认为δEF1家族蛋白通过抑制RGS16的表达直接或间接地促进乳腺癌细胞的运动。
The epithelial–mesenchymal transition (EMT) is associated with tumor progression. We reported previously that expression of the δEF1 family proteins (δEF1/ZEB1 and SIP1/ZEB2), key regulators of the EMT, is positively correlated with EMT phenotypes and aggressiveness of breast cancer. Here, we show that the expression levels of regulator of G‐protein signaling 16 (RGS16) are negatively correlated with those of the δEF1 family proteins. On the basis of the results of gain‐ and loss‐of‐function analyses, we suggest that δEF1 family proteins promote cell motility of breast cancer cells directly or indirectly through repressing expression of RGS16.