DECLINE IN THE PREDICTED INCIDENCE OF HUNTINGTON'S CHOREA ASSOCIATED WITH SYSTEMATIC GENETIC COUNSELLING AND FAMILY SUPPORT
DECLINE IN THE PREDICTED INCIDENCE OF HUNTINGTON'S CHOREA ASSOCIATED WITH SYSTEMATIC GENETIC COUNSELLING AND FAMILY SUPPORT
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亨廷顿舞蹈病的预测发病率下降与系统遗传咨询和家庭支持有关
DOI：
10.1016/s0140-6736(81)90845-x
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
V. Mcbroom
中科院分区：
文献类型：
--
作者：
P. Harper;Susan A. Smith;A. Tyler;P. Jones;R. Newcombe;V. Mcbroom
在一个先前记录的南威尔士高发病率人群中，对亨廷顿舞蹈病（HC）高风险亲属的前瞻性研究显示，与我们引入系统遗传咨询和家庭支持计划之前相对稳定的水平相比，有风险的出生人数和预测的未来疾病发病率明显下降。虽然风险分娩减少的原因可能很复杂，但似乎遗传咨询，即使在缺乏有效的预测和产前诊断测试的情况下，也可能有助于长期预防这一人群中的HC。
Prospective study of relatives at high risk of Huntington's chorea (HC) in a previously documented1South Wales population with a high incidence of the disorder has shown a pronounced fall in the number of births at risk and in the predicted future incidence of the disease, contrasting with relatively stable levels before the introduction of our programme of systematic genetic counselling and family support. Although the reasons for the reduction in births at risk are probably complex, it appears that genetic counselling, even in the absence of effective predictive and prenatal diagnostic tests, may be helpful in the long-term prevention of HC in this population.