Structural and functional brain asymmetries in human situs inversus totalis
Structural and functional brain asymmetries in human situs inversus totalis
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DOI：
10.1212/wnl.53.6.1260
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发表时间：
1999-10-12
期刊：
影响因子：
9.9
通讯作者：
Henson, JW
中科院分区：
文献类型：
--
作者：
Kennedy, DN;O'Craven, KM;Henson, JW
目的：为了确定患有全身性内脏逆位（CSI）的个体是否具有大脑不对称性的改变，在这种情况下，存在不对称内脏器官的镜像逆转。背景：人脑在结构和功能上是不对称的。虽然人脑解剖不对称性与功能偏侧化之间的相关性已被证实，但对其进行深入分析仍存在困难。表征SI中的脑结构和功能的不对称性可能会促进对这些关系的理解。方法：使用解剖和功能磁共振成像技术，我们分析了三个人与SI的大脑不对称。结果：两个主要的解剖不对称的大脑半球，额叶和枕叶花瓣，被逆转的个人与SI。相反，SI受试者在功能性MRI分析中具有左脑半球语言优势以及强右利手。结论：这些观察结果表明，决定大脑花瓣和内脏解剖不对称的发育因素与产生语言功能侧化的因素不同。
Objective: To determine whether individuals with situs inversus totalis CSI), a condition in which there is a mirror-image reversal of asymmetric visceral organs, have alterations in brain asymmetries. Background: The human brain is asymmetric in structure and function. Although correlations between anatomic asymmetries and functional lateralization in human brain have been demonstrated, it has been difficult tu further analyze them. Characterization of asymmetries of brain structure and function in SI might advance the understanding of these relationships. Methods: Using anatomic and functional MRI techniques, we analyzed asymmetries in the brains of three individuals with SI. Results: Two major anatomic asymmetries of the cerebral hemispheres, the frontal and occipital petalia, were reversed in individuals with SI. In contrast, SI subjects had left cerebral hemisphere language dominance on functional MRI analysis as well as strong right=handedness. Conclusion: These observations suggest that the developmental factors determining anatomic asymmetry of the cerebral petalia and viscera are distinct from those producing the functional lateralization of language.