Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome
Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome
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DOI：
10.1016/s0304-3940(96)13192-x
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发表时间：
1996-11-29
影响因子：
2.5
通讯作者：
Mayer, RJ
中科院分区：
文献类型：
--
作者：
Fergusson, J;Landon, M;Mayer, RJ
MS73是ATP酶家族的成员之一，作为26S蛋白酶体的调节亚基发挥作用。通过免疫组织化学方法检测了这种ATP酶在阿尔茨海默病（AD）患者海马组织切片以及路易体痴呆（DLB）患者扣带回切片中的定位情况。在所有10例AD病例中，神经原纤维缠结（NFT）、斑块神经突和神经毡细丝均对MS73呈免疫反应性。在9例DLB病例中的7例里，在皮质路易小体中检测到了独特的MS73阳性结构。MS73与这些神经元异常的关联进一步证明，涉及26S蛋白酶体的蛋白水解过程发生在AD和DLB的病变中。
MS73 is one of a family of ATPases that act as regulatory subunits of the 26S proteasome. Localisation of this ATPase in histological sections of hippocampus from Alzheimer's disease (AD) and in cingulate gyrus sections of dementia with Lewy bodies (DLB) brains was examined immunohistochemically. In all cases of AD (n=10) neurofibrillary tangles (NFT), plaque neurites and neuropil threads were immunoreactive for MS73. In seven out of the nine cases of DLB, distinctive MS73-positive structures were detected within cortical Lewy bodies. The association of MS73 with these neuronal abnormalities provides further evidence that proteolytic processing involving the 26S proteasome occurs in lesions of AD and DLB.