Cholesterol interactions with ceramide and sphingomyelin
Cholesterol interactions with ceramide and sphingomyelin
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DOI：
10.1016/j.chemphyslip.2016.04.002
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发表时间：
2016-09-01
影响因子：
3.4
通讯作者：
Goni, Felix M.
中科院分区：
文献类型：
--
作者：
Garcia-Arribas, Aritz B.;Alonso, Alicia;Goni, Felix M.
鞘脂在其极性头部中含有化学基团，允许它们与双层中的其他脂质建立复杂的H-键网络（通过不同的-OH和-NH-基团）。近年来，鞘磷脂（SM）与胆固醇（Chol）的特异性相互作用已被研究，主要是在“脂筏”假说的背景下。SM-神经酰胺（Cer）复合物的形成，建议存在于细胞膜中，以响应压力，也已被描述。最近，在SM，Chol和Cer的三元混合物中的相形成和转化的微妙平衡，Chol和Cer从它们与SM的相互作用相互置换被认为是存在的。此外，证明Chol-Cer直接相互作用的数据也越来越多。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Sphingolipids contain in their polar heads chemical groups allowing them to establish a complex network of H-bonds (through different -OH and -NH-groups) with other lipids in the bilayer. In the recent years the specific interaction of sphingomyelin (SM) with cholesterol (Chol) has been examined, largely in the context of the "lipid raft" hypothesis. Formation of SM-Ceramide (Cer) complexes, proposed to exist in cell membranes in response to stress, has also been described. More recently, a delicate balance of phase formation and transformation in ternary mixtures of SM, Chol and Cer, with mutual displacement of Chol and Cer from their interaction with SM is considered to exist. In addition, data demonstrating direct Chol-Cer interaction are becoming available. (C) 2016 Elsevier Ireland Ltd. All rights reserved.