Cardiovascular alteration by nucleus locus coeruleus in spontaneously hypertensive rat
Cardiovascular alteration by nucleus locus coeruleus in spontaneously hypertensive rat
复制标题
自发性高血压大鼠蓝核斑对心血管的改变
DOI：
10.1016/0006-8993(78)90243-3
复制
发表时间：
1978
期刊：
影响因子：
2.9
通讯作者：
E. Frohlich
中科院分区：
文献类型：
--
作者：
H. Kawamura;C. G. Gunn;E. Frohlich
正常血压大鼠（WKY）在50和100 μA时，蓝斑核（LC）的双相电刺激产生与心率增加相关的频率相关的加压反应。相比之下，自发性高血压大鼠（SHR）在50 μA和50 Hz的刺激下表现出较小的抑制反应，但在50或100 μA的刺激下没有持续的压力和心率变化。SHR组LCpressorthreshold电流（使动脉压升高≥10 mmhg所需的电流）高于WKY组（136±5 μA vs 84±7 μA, P < 0.001）；只有SHR LC表现出降压阈值（降低动脉压≥10 mm Hg所需的电流）（53±3 μA）。这些阈值电流水平似乎不会随着双侧颈动脉闭塞或颈动脉窦刺激引起的动脉压力的急性改变而改变。因此，这些研究表明，SHR的LC对刺激的反应水平发生了改变，但LC的升压功能似乎与SHR中异常高动脉压的进一步升高无关。
Biphasic electrical stimulation of the nucleus locus coeruleus (LC) produced frequency-related pressor responses associated with increased heart rate in normotensive rats (WKY) at both 50 and 100 μA. In contrast, spontaneously hypertensive rats (SHR) demonstrated small depressor responses at 50 μA and 50 Hz, but no consistent pressure or heart rate changes at either 50 or 100 μA stimulation. The LCpressorthreshold current (current necessary to increase arterial pressure by ≥ 10 mm Hg) was higher in SHR than WKY (136 ± 5 μA vs.84 ± 7 μA; P < 0.001); and only the SHR LC demonstrated adepressorthreshold (current necessary to reduce arterial pressure by ≥ 10 mm Hg) (53 ± 3 μA). These threshold current levels did not seem to change with acute alterations of arterial pressure produced by either bilateral carotid artery occlusion or carotid sinus stimulation. Therefore, these studies indicate altered levels of responsiveness of the SHR LC to stimulation but that the pressor function of the LC does not seem to be importantly involved in further elevation of abnormally high arterial pressure in the SHR.