Amino acid sequences of mouse complement C3 derived from nucleotide sequences of cloned cDNA.
Amino acid sequences of mouse complement C3 derived from nucleotide sequences of cloned cDNA.
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小鼠补体 C3 的氨基酸序列源自克隆 cDNA 的核苷酸序列。
DOI：
10.1111/j.1749-6632.1983.tb18118.x
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发表时间：
1983
影响因子：
5.2
通讯作者：
Domdey,H
中科院分区：
文献类型：
--
作者：
Fey,GH;Wiebauer,K;Domdey,H
补体系统由一组血浆蛋白组成，在高等脊椎动物抵抗微生物感染的防御中起重要作用。'.*此外，补体和补体衍生肽参与炎症反应和淋巴细胞对抗体合成的调节。补体的第三种成分，即1C3，是补体激活的经典途径和旁路途径的功能中的基本元件。C3最显著的特征之一是其与许多其他蛋白质特异性相互作用的能力，并且补体的经典和替代途径的活化的所有净效应取决于C3及其衍生物的这些相互作用：
The complement system consists of a group of plasma proteins that play an important role in the defense of higher vertebrates against microbial infections.'.* In addition, complement and complement-derived peptides participate in inflammatory reactions and in the regulation of antibody synthesis by lymphocytes.'-6 C3, d the third component of complement, is an essential element in the functioning of both the classical and the alternative pathways of complement activation. One of the most striking characteristics of C3 is its capacity to interact specifically with a number of other proteins, and all the net effects of activation of both the classical and the alternative pathways of complement depend upon these interactions of C3 and its derivatives: