Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module.
Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module.
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DOI：
10.1126/sciadv.1601314
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发表时间：
2017-03
期刊：
影响因子：
13.6
通讯作者：
Kim DH
中科院分区：
文献类型：
--
作者：
Lee H;Song C;Hong YS;Kim M;Cho HR;Kang T;Shin K;Choi SH;Hyeon T;Kim DH
开发了一种基于汗液的血糖监测装置，用于无创性糖尿病治疗。使用人体皮肤上的软生物电子学对汗液进行电化学分析，为无创血糖监测提供了一种新的途径，而无需痛苦的血液收集。然而，基于汗液的葡萄糖感测仍然面临许多挑战，例如汗液收集困难、由于乳酸分泌和环境温度变化导致的葡萄糖氧化酶活性变化以及酶在暴露于机械摩擦和皮肤变形时的分层。响应于所测量的葡萄糖水平的精确的床旁治疗仍然是非常具有挑战性的。我们提出了一种可穿戴/一次性的基于汗液的葡萄糖监测设备，该设备集成了反馈经皮给药模块。精心的多层贴片设计和传感器的小型化提高了汗液收集和传感过程的效率。多模式葡萄糖传感以及基于pH值、温度和湿度测量的实时校正，可最大限度地提高传感精度。相同传感器的最小布局设计还实现了条型一次性装置。用于反馈经皮治疗的药物被装载在两种不同的温度响应相变纳米颗粒上。这些纳米颗粒嵌入透明质酸水凝胶微针中，微针另外涂覆有相变材料。这使得能够响应于患者的葡萄糖水平进行多阶段的、空间模式化的和精确控制的药物释放。该系统为糖尿病的无创汗液管理提供了一种新的闭环解决方案。
A sweat-based glucose monitoring device with transdermal drug delivery is developed for noninvasive diabetes treatment. Electrochemical analysis of sweat using soft bioelectronics on human skin provides a new route for noninvasive glucose monitoring without painful blood collection. However, sweat-based glucose sensing still faces many challenges, such as difficulty in sweat collection, activity variation of glucose oxidase due to lactic acid secretion and ambient temperature changes, and delamination of the enzyme when exposed to mechanical friction and skin deformation. Precise point-of-care therapy in response to the measured glucose levels is still very challenging. We present a wearable/disposable sweat-based glucose monitoring device integrated with a feedback transdermal drug delivery module. Careful multilayer patch design and miniaturization of sensors increase the efficiency of the sweat collection and sensing process. Multimodal glucose sensing, as well as its real-time correction based on pH, temperature, and humidity measurements, maximizes the accuracy of the sensing. The minimal layout design of the same sensors also enables a strip-type disposable device. Drugs for the feedback transdermal therapy are loaded on two different temperature-responsive phase change nanoparticles. These nanoparticles are embedded in hyaluronic acid hydrogel microneedles, which are additionally coated with phase change materials. This enables multistage, spatially patterned, and precisely controlled drug release in response to the patient’s glucose level. The system provides a novel closed-loop solution for the noninvasive sweat-based management of diabetes mellitus.