Solid-phase synthesis of a pepticinnamin E library.
Solid-phase synthesis of a pepticinnamin E library.
复制标题
胃蛋白酶 E 文库的固相合成。
DOI：
10.1016/s0968-0896(03)00159-7
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发表时间：
2003
影响因子：
3.5
通讯作者：
H. Waldmann
中科院分区：
文献类型：
--
作者：
Michael Thutewohl;H. Waldmann
Pepticinnamin E is a naturally occurring bisubstrate inhibitor of farnesyltransferase. Based on the structure of the natural product, a compound library was synthesized by variation of eight structural parameters. Following three different routes, a total of 51 analogues was synthesized on the polymeric support in 6–11-step parallel syntheses. Overall yields ranged from 3 to 63%, and the compounds were obtained with >90% purity.
