Chromatin-mediated Candida albicans virulence
Chromatin-mediated Candida albicans virulence
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DOI：
10.1016/j.bbagrm.2011.08.007
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发表时间：
2012-03-01
影响因子：
4.7
通讯作者：
Kaufman, Paul D.
中科院分区：
文献类型：
--
作者：
da Rosa, Jessica Lopes;Kaufman, Paul D.
白色念珠菌是最常见的人类真菌病原体。为了成功传播感染，这种生物体依赖于改变形态、表达毒力相关基因和抵抗宿主免疫系统引起的 DNA 损伤的能力。其中许多事件涉及对毒力至关重要的染色质改变。本综述将重点关注染色质功能如何影响白色念珠菌和其他真菌致病性的研究。本文是题为：组蛋白伴侣和染色质组装的特刊的一部分。 (C) 2011 Elsevier B.V. 保留所有权利。
Candida albicans is the most prevalent human fungal pathogen. To successfully propagate an infection, this organism relies on the ability to change morphology, express virulence-associated genes and resist DNA damage caused by the host immune system. Many of these events involve chromatin alterations that are crucial for virulence. This review will focus on the studies that have been conducted on how chromatin function affects pathogenicity of C. albicans and other fungi. This article is part of a Special Issue entitled: Histone chaperones and Chromatin assembly. (C) 2011 Elsevier B.V. All rights reserved.