Race, borderline hypertension, and hemodynamic responses to behavioral stress before and after beta-adrenergic blockade.
Race, borderline hypertension, and hemodynamic responses to behavioral stress before and after beta-adrenergic blockade.
复制标题
种族、临界高血压以及β-肾上腺素能阻断前后对行为压力的血流动力学反应。
DOI：
10.1037//0278-6133.8.5.577
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Sherwood,A
中科院分区：
文献类型：
--
作者：
Light,KC;Sherwood,A
血压（BP）和血流动力学反应（心输出量[CO]和总外周阻力[TPR]）的竞争性反应时间的任务，以前被证明增加β-肾上腺素能活性，在20名黑人和20名白色年轻男子进行了比较，一次后输注生理盐水安慰剂，后来重复后输注非选择性β-受体拮抗剂，普萘洛尔。两个人种组均包括边缘收缩压（SBP）升高的受试者（n= 6例白人，n= 5例黑人）和血压正常的受试者（n= 14例白人，n= 15例黑人）。在压力刺激过程中，SBP边缘升高的黑人比他们的白色同伴表现出更大的舒张压升高，无论是在β受体阻滞剂之前还是之后。在任务过程中，SBP轻微升高的黑人和白人的CO增加幅度均大于阻滞前血压正常者。独立于BP状态，黑人受试者对任务的TPR反应始终高于白人（阻滞前降低较少，阻滞后增加较多）。黑人也表现出更大的减少比白人阻断后的离子型心肌反应（每搏输出量，射血前期，和CO）的压力。α-肾上腺素能和β-肾上腺素能的影响，这些种族群体差异的可能贡献进行了讨论。
Blood pressure (BP) and hemodynamic responses (cardiac output [CO] and total peripheral resistance [TPR]) to a competitive reaction-time task, previously shown to increase beta-adrenergic activity, were compared in 20 Black and 20 White young men, once following infusion of saline placebo and later repeated after infusion of the nonselective beta-antagonist, propranolol. Both racial groups included subjects with marginal systolic BP (SBP) elevations (n= 6 Whites, n= 5 Blacks) and subjects with normal BP (n= 14 Whites, n= 15 Blacks). Blacks with marginal SBP elevations showed greater diastolic BP increases during the stressor than their White counterparts, both before and after beta-blockade. Both Blacks and Whites with marginal SBP elevations showed greater CO increases during the task than normotensives prior to blockade. Independent of BP status, Black subjects consistently showed higher TPR responses to the task than Whites (lesser decreases before blockade and greater increases after blockade). Blacks also showed greater diminution than Whites after blockade in ionotropic myocardial responses (stroke volume, pre-ejection period, and CO) to the stressor. The possible contributions of alpha-adrenergic and beta-adrenergic influences to these racial group differences are discussed.