A canonical correlation analysis of the relationship between clinical attributes and patient-specific hemodynamic indices in adult pulmonary hypertension
A canonical correlation analysis of the relationship between clinical attributes and patient-specific hemodynamic indices in adult pulmonary hypertension
复制标题
DOI：
10.1016/j.medengphy.2020.01.006
复制
发表时间：
2020-03-01
影响因子：
2.2
通讯作者：
Finol, Ender A.
中科院分区：
文献类型：
--
作者：
Piskin, Senol;Patnaik, Sourav S.;Finol, Ender A.
肺动脉高压（PH）是一种进行性疾病，发病率约为10-52 /百万人，女性发病率较高，且与右心室（RV）衰竭相关的死亡率较高。在这项工作中，我们探讨了从肺循环计算机模型计算的血流动力学指标与右心室负荷的临床属性和病理特征之间的关系。从计算机断层扫描血管造影图像中重建34个患者特定的肺动脉树几何形状，并用于随后的计算流体动力学（CFD）模拟的体积网格划分。从CFD模拟中获得的数据进行后处理，得到代表血流动力学的血流动力学指标。对医疗记录进行回顾性审查，以收集从标准医院检查中测量或计算的临床变量。对临床指标和血流动力学指标进行统计分析和典型相关分析（CCA）。收缩期肺动脉压（sPAP）、舒张期肺动脉压（dPAP）、心输出量（CO）和脑卒中容积（SV）与空间平均壁剪应力(0.60
Pulmonary hypertension (PH) is a progressive disease affecting approximately 10-52 cases per million, with a higher incidence in women, and with a high mortality associated with right ventricle (RV) failure. In this work, we explore the relationship between hemodynamic indices, calculated from in silico models of the pulmonary circulation, and clinical attributes of RV workload and pathological traits. Thirty-four patient-specific pulmonary arterial tree geometries were reconstructed from computed tomography angiography images and used for volume meshing for subsequent computational fluid dynamics (CFD) simulations. Data obtained from the CFD simulations were post-processed resulting in hemodynamic indices representative of the blood flow dynamics. A retrospective review of medical records was performed to collect the clinical variables measured or calculated from standard hospital examinations. Statistical analyses and canonical correlation analysis (CCA) were performed for the clinical variables and hemodynamic indices. Systolic pulmonary artery pressure (sPAP), diastolic pulmonary artery pressure (dPAP), cardiac output (CO), and stroke volume (SV) were moderately correlated with spatially averaged wall shear stress (0.60