To Freeze or Not to Freeze? An Update on Fertility Preservation In Females with Turner Syndrome
To Freeze or Not to Freeze? An Update on Fertility Preservation In Females with Turner Syndrome
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DOI：
10.17458/per.vol16.2019.svb.tofreezeornot
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发表时间：
2019-03-01
影响因子：
--
通讯作者：
Fleischer, K.
中科院分区：
文献类型：
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作者：
Schleedoorn, M. J.;van Alfen-van der Velden;Fleischer, K.
不育是特纳综合征（TS）女性的主要问题，无论他们的年龄。虽然生育保留现在常规提供给女孩和年轻女性癌症，目前没有关于生育保留的女孩和年轻女性TS谁通常面临更高的不孕风险的建议。尽管缺乏国际准则，保存程序已进行实验性的女性TS。MethodsA系统的文献检索的基础上的PRISMA-P方法进行系统评价，以收集所有已发表的数据生育力保存选项的女性TS之间的1980年1月至2018年4月。本次审查共纳入67条记录。筛选记录中关于冷冻保存TS女性成熟卵母细胞和卵巢组织的信息。两个正在进行的试验生育保存年轻女性TS也included.ResultsCryopreservation卵母细胞或卵巢组织已进行实验在>150个女孩和青少年TS在过去的16年。TS女性的生育力保存选项的疗效仍然是未知的，由于缺乏后续data.ConclusionThe女性TS生育力保存程序的疗效仍然未知。未来的研究重点是疗效，安全性和长期随访是迫切需要的。
IntroductionInfertility is a major concern for females with Turner syndrome (TS), regardless of their age. While fertility preservation is now routinely offered to girls and young women with cancer, there are currently no recommendations on fertility preservation in girls and young women with TS who generally face an even higher risk for infertility. Despite the lack of international guidelines, preservation procedures have been performed experimentally in females with TS.MethodsA systematic literature search based on the PRISMA-P methodology for systematic reviews was performed in order to collect all published data on fertility preservation options in females with TS between January 1980 and April 2018. A total number of 67 records were included in this review. The records were screened for information regarding cryopreservation of mature oocytes and ovarian tissue in females with TS. Two ongoing trials on fertility preservation in young females with TS were also included.ResultsCryopreservation of oocytes or ovarian tissue has been performed experimentally in >150 girls and adolescents with TS over the last 16 years. The efficacy of fertility preservation options in females with TS is still unknown due to the lack of follow-up data.ConclusionThe efficacy of fertility preservation procedures in females with TS is still unknown. Future studies with focus on efficacy, safety and long-term follow-up are desperately needed.