Effect of inhibition of alpha-glucosidase on age-related glucose intolerance and pancreatic atrophy in rats.
Effect of inhibition of alpha-glucosidase on age-related glucose intolerance and pancreatic atrophy in rats.
复制标题
抑制α-葡萄糖苷酶对大鼠年龄相关的葡萄糖耐受不良和胰腺萎缩的影响。
DOI：
10.1016/j.metabol.2005.11.007
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
M. Otsuki
中科院分区：
文献类型：
--
作者：
Mitsuyoshi Yamamoto;M. Otsuki
口服α-葡萄糖苷酶抑制剂可降低餐后血清葡萄糖和胰岛素浓度；因此，α-葡萄糖苷酶抑制剂在世界范围内被用于糖尿病的治疗。在我们的研究中，我们评估了α-葡萄糖苷酶抑制剂阿卡波糖对Long-Evans德岛大鼠（LETO）年龄相关性葡萄糖耐受不良和胰腺萎缩的影响。第一组大鼠接受标准大鼠饮食（对照组）。第二组小鼠从12 ~ 28周龄开始饲喂含阿卡波糖（150 mg/100 g）的日粮，然后改为标准大鼠日粮，直至72周龄（a12 ~ 28w）。第三组12 ~ 72周龄（a12 ~ 72w）饲喂含阿卡波糖的相同饲粮。对照组空腹血糖和胰岛素浓度随着年龄的增长逐渐升高，但阿卡波糖治疗完全阻止了（A12-72W）或延缓了（A12-28W）这种升高。此外，阿卡波糖治疗可防止胰岛素抵抗随年龄增长而恶化。72周龄时，A12-72W组胰腺湿重和DNA含量显著高于对照组。虽然对照组中大多数胰岛增大，胰腺组织的某些部分含有脂肪和结缔组织，但这些变化在A12-28W组中是轻微的，在A12-72W组中保持最小。我们的研究表明，阿卡波糖可用于预防与年龄相关的葡萄糖耐受不良和胰腺萎缩。
Oral administration of α-glucosidase inhibitor reduces postprandial serum glucose and insulin concentrations; thus, α-glucosidase inhibitor is used for the treatment of diabetes mellitus worldwide. In our study, we have evaluated the effect of α-glucosidase inhibitor, acarbose, on age-related glucose intolerance and pancreatic atrophy in the Long-Evans Tokushima Otsuka (LETO) rat. The first group of rats received a standard rat diet (control). The second group received a diet containing acarbose (150 mg/100 g food) from 12 to 28 weeks and then switched to a standard rat diet until 72 weeks of age (A12-28W). The third group was administered the same diet containing acarbose from 12 to 72 weeks of age (A12-72W). Fasting serum glucose and insulin concentrations gradually increased with increasing age in the control group, but these increases were completely prevented (A12-72W) or delayed (A12-28W) by acarbose treatment. In addition, acarbose treatment prevented the deterioration in insulin resistance with increasing age. At 72 weeks of age, pancreatic wet weight and DNA content in the A12-72W group were significantly higher than those in the control group. Although most islets were enlarged, and some portions of pancreatic tissue contained fatty and connective tissue in the control group, these alterations were mild in the A12-28W group and remained minimal in the A12-72W group. Our study suggests that acarbose is useful in the prevention of age-related glucose intolerance and pancreatic atrophy.
影响因子：
15.9
作者：
Barzilai, N;Banerjee, S;Rossetti, L
通讯作者：
Rossetti, L