A test of the master gene hypothesis for interspersed repetitive DNA sequences
A test of the master gene hypothesis for interspersed repetitive DNA sequences
复制标题
DOI：
10.1093/molbev/msj034
复制
发表时间：
2006-02-01
影响因子：
10.7
通讯作者：
Brookfield, JFY
中科院分区：
文献类型：
--
作者：
Johnson, LJ;Brookfield, JFY
许多散布的重复DNA元件家族，包括人类Alu和LINE（长散布元件）元件，已经被认为是通过从单一来源基因座（“主基因”）重复复制而积累的。“主基因模型的适用范围对这些序列的起源，进化和功能有影响。啮齿动物的ID（标识符）元件是一个重复元件家族，其主基因的一个令人信服的案例已经被提出。在这里，我们设计了一个新的测试的主基因模型，并使用它来显示，小鼠ID元件序列是不兼容的一个严格的主基因模型。我们认为，一个单一的主基因是很少的，如果有的话，可能是负责任何重复家庭的积累。
Many families of interspersed repetitive DNA elements, including human Alu and LINE (Long Interspersed Element) elements, have been proposed to have accumulated through repeated copying from a single source locus: the "master gene." The extent to which a master gene model is applicable has implications for the origin, evolution, and function of such sequences. One repetitive element family for which a convincing case for a master gene has been made is the rodent ID (identifier) elements. Here we devise a new test of the master gene model and use it to show that mouse ID element sequences are not compatible with a strict master gene model. We suggest that a single master gene is rarely, if ever, likely to be responsible for the accumulation of any repeat family.