Finding alternatives to antibiotics
Finding alternatives to antibiotics
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DOI：
10.1111/nyas.12468
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发表时间：
2014-01-01
期刊：
影响因子：
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通讯作者：
Casey, Thomas A.
中科院分区：
文献类型：
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作者：
Allen, Heather K.;Trachsel, Julian;Casey, Thomas A.
抗药性病原体的传播需要新的治疗方法。随着新抗生素的开发速度严重下降，在畜牧业和人类医学中必须考虑抗生素的替代品。预防疾病的产品不同于治疗疾病的产品，这里讨论两者的例子。例如，通过饲料添加剂或粪便移植调节肠道微生物群落可能是预防某些疾病的有希望的方法;对于疾病治疗，非抗生素方法包括噬菌体治疗，噬菌体溶素，细菌素和捕食性细菌。有趣的是，这些方法中的几种通过提高细菌杀灭和减少抗生素抗性选择来增强抗生素功效。由于细菌最终会对几乎任何治疗药物产生耐药性，因此继续明智地使用抗生素及其替代品非常重要。
The spread of antibiotic-resistant pathogens requires new treatments. As the rate of development of new antibiotics has severely declined, alternatives to antibiotics must be considered in both animal agriculture and human medicine. Products for disease prevention are different from those for disease treatment, and examples of both are discussed here. For example, modulating the gut microbial community, either through feed additives or fecal transplantation, could be a promising way to prevent certain diseases; for disease treatment, non-antibiotic approaches include phage therapy, phage lysins, bacteriocins, and predatory bacteria. Interestingly, several of these methods augment antibiotic efficacy by improving bacterial killing and decreasing antibiotic resistance selection. Because bacteria can ultimately evolve resistance to almost any therapeutic agent, it is important to continue to use both antibiotics and their alternatives judiciously.