Fear conditioning enhances different temporal components of tone-evoked spike trains in auditory cortex and lateral amygdala
Fear conditioning enhances different temporal components of tone-evoked spike trains in auditory cortex and lateral amygdala
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DOI：
10.1016/s0896-6273(00)80375-x
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发表时间：
1997-09-01
期刊：
影响因子：
16.2
通讯作者：
LeDoux, JE
中科院分区：
文献类型：
--
作者：
Quirk, GJ;Armony, JL;LeDoux, JE
在恐惧条件化的自由行为大鼠中，记录了从听觉皮质投射到杏仁外侧核(LA)的区域的单个神经元。分析了条件化和消退的潜伏期和消失率，并将结果与来自LA本身的先前记录进行了比较。听觉皮质神经元经历了更多的试验才能学习，而且在试验中它们的反应比LA神经元慢。因此，LA的短潜伏期可塑性反映了来自听觉丘脑而不是听觉皮质的输入。与LA细胞不同，一些听觉皮质细胞表现出晚条件反应，似乎预见到了非条件刺激，而另一些细胞则表现出抗消退的记忆存储。因此，对潜在危险刺激的恐惧反应的快速条件化依赖于杏仁核的可塑性，而皮质区域可能特别参与对恐惧经历的高级认知(助记和注意)处理。
Single neurons were recorded in freely behaving rats during fear conditioning from areas of auditory cortex that project to the lateral nucleus of the amygdala (LA). The latency and rate of conditioning and extinction were analyzed, and the results were compared to previous recordings from LA itself. Auditory cortex neurons took more trials to learn, and they responded more slowly than LA neurons within trials. Short-latency plasticity in LA, therefore, reflects inputs from the auditory thalamus rather than the auditory cortex. Unlike LA cells, some auditory cortex cells showed late conditioned responses that seemed to anticipate the unconditioned stimulus, while others showed extinction-resistant memory storage. Thus, rapid conditioning of fear responses to potentially dangerous stimuli depends on plasticity in the amygdala, while cortical areas may be particularly involved in higher cognitive (mnemonic and attentional) processing of fear experiences.