MOUSE ONCOGENE PROTEIN-24P3 IS A MEMBER OF THE LIPOCALIN PROTEIN FAMILY
MOUSE ONCOGENE PROTEIN-24P3 IS A MEMBER OF THE LIPOCALIN PROTEIN FAMILY
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DOI：
10.1016/s0006-291x(05)81256-2
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发表时间：
1991-10-15
影响因子：
3.1
通讯作者：
ATTWOOD, TK
中科院分区：
文献类型：
--
作者：
FLOWER, DR;NORTH, ACT;ATTWOOD, TK
蛋白质序列分析的严格的新方法已被应用于脂质运载蛋白，一个不同的配体结合蛋白家族。利用三个保守的序列基序在大型序列数据库中搜索相似的模式，以自动和客观的方式确定了该蛋白质家族的大小和组成。它允许识别现有的序列，小鼠24p3蛋白，作为脂质运载蛋白和可能的排斥其他推定的成员从这个蛋白质家族。基于这一新发现的同源性，提出了小鼠24p3蛋白的可能功能。
Rigorous new methods of protein sequence analysis have been applied to the lipocalins, a diverse family of ligand binding proteins. Using three conserved sequence motifs to search for similar patterns in a large sequence database, the size and composition of this protein family have been defined in an automatic and objective way. It has allowed the identification of an existing sequence, mouse 24p3 protein, as a lipocalin and the possible rejection of other putative members from this protein family. On the basis of this newly discovered homology, a possible function for mouse 24p3 protein is proposed.