Account: An introduction to velocity-map imaging mass spectrometry (VMImMS)
Account: An introduction to velocity-map imaging mass spectrometry (VMImMS)
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DOI：
10.1255/ejms.1264
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发表时间：
2014-01-01
影响因子：
1.3
通讯作者：
Valiance, Claire
中科院分区：
文献类型：
--
作者：
Bull, James N.;Lee, Jason W. L.;Valiance, Claire
该帐户介绍了一种新的变体的飞行时间质谱，称为速度图成像质谱（VMImMS）。虽然在常规ToF-MS测量中记录的离子丰度对于分子定量和结构确定非常有用，但最终的母离子和碎片离子产率在很大程度上对离子在质谱仪内形成的过程的动力学是盲目的。通过与质谱串联记录每个离子的速度分布，不仅可以解开解离电离动力学的细节，而且可以将额外维度的信息用于增强分子指纹识别，分离具有相同质荷比的离子的贡献，并解析混合物中的组分，仅举几个例子。在质谱测量中测量离子速度分布并不新鲜，但结合反应动力学社区内开发的成像技术，在单级仪器中同时为所有离子提供了大大提高的速度分辨率。该帐户提供了一个VMImMS的介绍，概述了基本的仪器和检测器的要求，并与进一步开发的方法相关的挑战，并详细介绍了我们的实验室的概念验证工作的一些潜在的应用该技术。
This account introduces a new variant of time-of-flight mass spectrometry, termed velocity-map imaging mass spectrometry (VMImMS). While the ion abundances recorded in conventional ToF-MS measurements are highly useful for molecular quantification and structure determination, the final parent and fragment ion yields are largely blind to the dynamics of the processes in which the ions were formed inside the mass spectrometer. By recording the velocity distribution of each ion in tandem with the mass spectrum, not only can the details of the dissociative ionisation dynamics be unravelled, but the extra dimensions of information can be used for enhanced molecular fingerprinting, separating contributions from ions with identical mass-to-charge ratio and resolving components within mixtures, to name but a few examples. Measuring ion-velocity distributions within a mass spectrometry measurement is not new, but incorporating imaging techniques developed within the reaction dynamics community provides vastly improved velocity resolution for all ions simultaneously in a single-stage instrument. This account provides an introduction to VMImMS, outlines the fundamental instrumentation and detector requirements and the challenges associated with developing the method further, and details proof-of-concept work from our laboratory on a number of potential applications of the technique.