HYDROGEN-PEROXIDE INDUCES SPAWNING IN MOLLUSKS, WITH ACTIVATION OF PROSTAGLANDIN ENDOPEROXIDE SYNTHETASE
HYDROGEN-PEROXIDE INDUCES SPAWNING IN MOLLUSKS, WITH ACTIVATION OF PROSTAGLANDIN ENDOPEROXIDE SYNTHETASE
复制标题
DOI：
10.1126/science.403609
复制
发表时间：
1977-01-01
期刊：
影响因子：
56.9
通讯作者：
MORSE, A
中科院分区：
文献类型：
--
作者：
MORSE, DE;DUNCAN, H;MORSE, A
在海水中加入过氧化氢会导致怀孕的雄性和雌性鲍鱼（Haliotis rufescens）和某些其他软体动物（如Mytilus california）同步产卵。这种作用被动物暴露于阿司匹林（一种催化前列腺素内过氧化物氧化合成的酶抑制剂）所阻断。过氧化氢在鲍鱼卵（前列腺素内过氧化物合成酶的一种非常丰富的来源）制备的无细胞提取物中激活这种酶促反应；这种效应似乎揭示了前列腺素内过氧化物合成的一个基本特性。建议这些发现适用于海水养殖和医疗目的。
Addition of hydrogen peroxide to seawater causes synchronous spawning in gravid male and female abalones [Haliotis rufescens] and certain other mollusks [e.g., Mytilus californianus] as well. This effect is blocked by exposure of the animals to aspirin, an inhibitor of the enzyme catalyzing oxidative synthesis of prostaglandin endoperoxide. Hydrogen peroxide activates this enzymatic reaction in cell-free extracts prepared from abalone eggs (a very rich source of the prostaglandin endoperoxide synthetase); this effect appears to reveal a fundamental property of prostaglandin endoperoxide synthesis. Applicability of these findings to mariculture and medical purposes is suggested.