INFLUENCE OF PHENOBARBITAL ON BIOTRANSFORMATION OF 25-HYDROXYCHOLECALCIFEROL
INFLUENCE OF PHENOBARBITAL ON BIOTRANSFORMATION OF 25-HYDROXYCHOLECALCIFEROL
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DOI：
10.1002/j.1552-4604.1976.tb02413.x
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发表时间：
1976-01-01
影响因子：
2.9
通讯作者：
TOLMAN, KG
中科院分区：
文献类型：
--
作者：
BURT, R;FRESTON, JW;TOLMAN, KG
在大鼠体内研究了苯巴比妥对25-OHD 3 [25-羟基胆钙化醇]生物转化为1，25-（OH）2-D3 [1，25-二羟基胆钙化醇]的影响。25-OHD 3的消失率在苯巴比妥治疗组（re [消退率] = 0.0615 pmol/min）和对照组（re = 0.0549 pmol/min）中几乎相同。1，25-（OH）2D 3的出现率在治疗组（ra [出现率] = 0.0133 pmol/min）和对照组（ra = 0.0134 pmol/min）中几乎相同。很可能，苯巴比妥不影响25-OHD 3到1，25-（OH）2D 3的生物转化，维生素D代谢的改变不能解释苯巴比妥诱导的骨软化症。
The effect of phenobarbital on the biotransformation of 25-OHD3 [25-hydroxycholecalciferol] to 1,25-(OH)2-D3 [1,25-dihydroxycholecalciferol] was studied in rats. The disappearance rate of 25-OHD3 was virtually the same in the phenobarbital-treated group (re [extinction rate] = 0.0615 pmol/min) and the control group (re = 0.0549 pmol/min). The appearance rate of 1,25-(OH)2D3 was virtually the same in the treated group (ra [appearance rate] = 0.0133 pmol/min) and the control group (ra = 0.0134 pmol/min). Probably, phenobarbital does not affect the biotransformation of 25-OHD3 to 1,25-(OH)2D3 and altered vitamin D metabolism does not account for phenobarbital-induced osteomalacia.