Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs
Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs
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DOI：
10.1038/nn1334
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发表时间：
2004-11-01
影响因子：
25
通讯作者：
Huang, ZJ
中科院分区：
文献类型：
--
作者：
Di Cristo, G;Wu, CZ;Huang, ZJ
不同类型的 GABA 能突触以受限的亚细胞域为目标，从而差异化地调节主要神经元的输入、整合和输出，但这种突触分离的潜在机制尚不清楚。在这里，我们表明，两类主要的 GABA 能突触沿着锥体神经元的体周和树突域的分布在体内初级视觉皮层和皮质器官型培养物之间无法区分。因此，亚细胞突触靶向独立于丘脑输入，并且可能涉及分子标记和与经验无关的活动形式。
Distinct classes of GABAergic synapses target restricted subcellular domains, thereby differentially regulating the input, integration and output of principal neurons, but the underlying mechanism for such synapse segregation is unclear. Here we show that the distributions of two major classes of GABAergic synapses along the perisomatic and dendritic domains of pyramidal neurons were indistinguishable between primary visual cortex in vivo and cortical organotypic cultures. Therefore, subcellular synapse targeting is independent of thalamic input and probably involves molecular labels and experience-independent forms of activity.