Atherosclerosis, vascular remodeling, and impairment of endothelium-dependent relaxation in genetically altered hyperlipidemic mice
Atherosclerosis, vascular remodeling, and impairment of endothelium-dependent relaxation in genetically altered hyperlipidemic mice
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DOI：
10.1161/01.atv.17.11.2333
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发表时间：
1997-11-01
影响因子：
8.7
通讯作者：
Faraci, FM
中科院分区：
文献类型：
--
作者：
Bonthu, S;Heistad, DD;Faraci, FM
我们研究了两种高胆固醇血症遗传模型：载脂蛋白E（apoE）基因敲除小鼠和联合apoE/LDL受体双敲除小鼠的血管结构和内皮依赖性舒张。apoE/LDL受体敲除小鼠胸主动脉近段内膜面积[0.13 ± 0.03（mean ± SE）mm（2）]较正常（C57 BL/6 J）小鼠（0.002 ± 0.002 mm（2），P
We examined the vascular structure and endothelium-dependent relaxation in two genetic models of hypercholesterolemia: apolipoprotein E (apoE)-knockout mice and combined apoE/LDL receptor-double-knockout mice. Intimal area was increased markedly in proximal segments of thoracic aortas from apoE/LDL receptor-knockout mice [0.13+/-0.03 (mean+/-SE) mm(2)] compared with normal (C57BL/6J) mice (0.002+/-0.002 mm(2), P