Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity.
Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity.
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DOI：
10.1016/j.neuron.2009.03.029
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发表时间：
2009-05-14
期刊：
影响因子：
16.2
通讯作者：
Tsai, Li-Huei
中科院分区：
文献类型：
--
作者：
Frank, Christopher L.;Tsai, Li-Huei
最近的研究表明，循环细胞与有丝分裂后神经元之间的界限并不像预期的那么具体。神经元中新颖且独特的生理功能被归因于细胞周期进程和控制所必需的蛋白质。这些“核心”细胞周期调节因子具有多种有丝分裂后功能，涵盖神经元的各个发育阶段，包括神经元迁移、轴突伸长、轴突修剪、树突形态发生以及突触成熟和可塑性。在这篇综述中，我们详细介绍了最近报道的这些细胞周期蛋白发挥的非增殖性有丝分裂后作用、它们在神经元中表达的重要性、可用的机制见解以及未来的前景。
Recent studies have demonstrated that boundaries separating a cycling cell from a post-mitotic neuron are not as concrete as expected. Novel and unique physiological functions in neurons have been ascribed for proteins fundamentally required for cell cycle progression and control. These “core” cell cycle regulators serve diverse post-mitotic functions that span various developmental stages of a neuron, including neuronal migration, axonal elongation, axon pruning, dendrite morphogenesis, and synaptic maturation and plasticity. In this review, we detail the non-proliferative post-mitotic roles that these cell cycle proteins have recently been reported to play, the significance of their expression in neurons, mechanistic insight when available, and future prospects.
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影响因子：
56.9
作者：
Ding, Mei;Chao, Dan;Shen, Kang
通讯作者：
Shen, Kang
DOI：
10.1074/jbc.m802475200
发表时间：
2008-10-24
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Ang XL;Seeburg DP;Sheng M;Harper JW
通讯作者：
Harper JW
影响因子：
64.8
作者：
Bashir, T;Dorrello, NV;Pagano, M
通讯作者：
Pagano, M
影响因子：
9.2
作者：
Cuvier, O;Lutzmann, M;Méchali, M
通讯作者：
Méchali, M
影响因子：
64.8
作者：
Chen, MS;Huber, AB;Schwab, ME
通讯作者：
Schwab, ME