Melanoma cell expression of Fas(Apo-1/CD95) ligand: Implications for tumor immune escape
Melanoma cell expression of Fas(Apo-1/CD95) ligand: Implications for tumor immune escape
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DOI：
10.1126/science.274.5291.1363
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发表时间：
1996-11-22
期刊：
影响因子：
56.9
通讯作者：
Tschopp, J
中科院分区：
文献类型：
--
作者：
Hahne, M;Rimoldi, D;Tschopp, J
恶性黑色素瘤是皮肤癌死亡率增加的主要原因。黑色素瘤细胞表达Fas(也称为Apo-1或CD95)配体(Fast)。在转移灶中，表达Fas的T细胞位于FasL(+)肿瘤细胞附近。在体外，Fas敏感的靶细胞与黑色素瘤细胞孵育后发生凋亡；在体内，注射FasL(+)小鼠黑色素瘤细胞导致快速肿瘤形成。相反，在Fas缺陷的LPR突变小鼠中，免疫效应细胞不能被Fast杀死的肿瘤发生被推迟。因此，FAST可能有助于肿瘤的免疫豁免。
Malignant melanoma accounts for most of the increasing mortality from skin cancer. Melanoma cells were found to express Fas (also called Apo-1 or CD95) ligand (Fast). In metastatic lesions, Fas-expressing T cell infiltrates were proximal to FasL(+) tumor cells. In vitro, apoptosis of Fas-sensitive target cells occurred upon incubation with melanoma tumor cells; and in vivo, injection of FasL(+) mouse melanoma cells in mice led to rapid tumor formation. In contrast, tumorigenesis was delayed in Fas-deficient lpr mutant mice in which immune effector Cells cannot be killed by Fast. Thus, Fast may contribute to the immune privilege of tumors.