Tick microbiome and pathogen acquisition altered by host blood meal
Tick microbiome and pathogen acquisition altered by host blood meal
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DOI：
10.1038/ismej.2016.152
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Andrea Swei;Jessica Y Kwan
中科院分区：
文献类型：
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作者：
Andrea Swei;Jessica Y Kwan
莱姆病是一种人畜共患疾病，是北方最流行的病媒传播疾病。媒介（蜱）微生物组的多样性可以影响病原体的传播，但驱动微生物组多样性的生物和非生物因素在很大程度上尚未解决，特别是在自然的野外条件下。我们描述了美国西部莱姆病的传播媒介太平洋硬蜱的微生物组，并显示了宿主血粉身份对蜱微生物组物种丰富度和组成的强烈影响。西方栅栏蜥蜴，一种对莱姆病病原体难治的宿主，相对于以哺乳动物储库宿主为食的蜱虫，显著降低了蜱虫中的微生物组多样性。宿主血餐驱动的蜱虫微生物组多样性减少可能对I. pacificusvector竞争力and ultimately最终disease疾病dynamics动态.
Lyme disease, a zoonotic disease, is the most prevalent vector-borne disease in the Northern Hemisphere. Diversity of the vector (tick) microbiome can impact pathogen transmission, yet the biotic and abiotic factors that drive microbiome diversity are largely unresolved, especially under natural, field conditions. We describe the microbiome ofIxodes pacificusticks, the vector for Lyme disease in the western United States, and show a strong impact of host blood meal identity on tick microbiome species richness and composition. Western fence lizards, a host that is refractory to the Lyme disease pathogen, significantly reduces microbiome diversity in ticks relative to ticks that feed on a mammalian reservoir host. Host blood meal-driven reduction of tick microbiome diversity may have lifelong repercussions onI. pacificusvector competency and ultimately disease dynamics.