A case of giant cell myocarditis and malignant thymoma: A postmortem diagnosis by needle biopsy
A case of giant cell myocarditis and malignant thymoma: A postmortem diagnosis by needle biopsy
复制标题
DOI：
10.1002/clc.4960210109
复制
发表时间：
1998-01-01
影响因子：
2.7
通讯作者：
Surks, HK
中科院分区：
文献类型：
--
作者：
Kilgallen, CM;Jackson, E;Surks, HK
本文报告一例暴发性巨细胞心肌炎合并恶性胸腺瘤导致死亡的46岁妇女。虽然生前曾怀疑诊断为巨细胞性心肌炎，但尸检后证实为巨细胞性心肌炎。只有经皮心脏穿刺活检获得同意。为了尊重家属的意愿并获得足够的诊断心肌，我们设计了一种简单的针穿刺活检技术。将骨髓环钻针连接到一个20英里的注射器上，通过抽吸，多次灌满15个组织盒。岩心立即置于福尔马林和B5固定液中。获得了高质量的组织保存，无挤压伪影。活检组织的免疫组化研究证实巨细胞为巨噬细胞来源。
This paper reports a case of fulminant giant cell myocarditis arising in association with a malignant thymoma causing death in a 46-year-old woman. Although the diagnosis was suspected in life, postmortem examination was required for confirmation of giant cell myocarditis. Consent was obtained only for percutaneous needle biopsy of the heart. In or der to respect the family's wishes and harvest sufficient diagnostic myocardium, a simple needle-based biopsy technique was devised. A bone marrow trephine needle was attached to a 20 mi syringe and, with suction, multiple passes were used to fill 15 tissue cassettes. The cores were placed immediately in formalin and B5 fixatives. High-quality tissue preservation was obtained without crush artefact. Immunohistochemical studies of the biopsy tissue confirmed that the giant cells were of macrophage derivation.