Renal protection by atorvastatin in a murine model of sickle cell nephropathy.
Renal protection by atorvastatin in a murine model of sickle cell nephropathy.
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阿托伐他汀在镰状细胞肾病小鼠模型中的肾脏保护作用。
DOI：
10.1111/bjh.15157
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发表时间：
2018-04
影响因子：
6.5
通讯作者：
Archer DR
中科院分区：
文献类型：
--
作者：
Zahr RS;Chappa P;Yin H;Brown LA;Ataga KI;Archer DR
Recent studies have demonstrated pleiotropic effects of statins in various mouse models of kidney disease. In this study, Townes humanized sickle cell mice were treated for 8 weeks with atorvastatin at a dose of 10 mg/kg/day starting at 10 weeks of age. Treatment with atorvastatin significantly reduced albuminuria, and improved both urine concentrating ability and glomerular filtration rate. Atorvastatin also decreased markers of kidney injury and endothelial activation, and ameliorated oxidant stress in renal tissues and peripheral macrophages. Atorvastatin downregulated the expression of mRNA levels of the NADPH oxidases, Cybb (also termed Nox2) and Nox4, which are major sources of oxidant stress in the kidney. These findings highlight the pleiotropic effects of atorvastatin and suggest that it may provide beneficial effects in sickle cell nephropathy.
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影响因子：
158.5
作者：
Miller, ST;Sleeper, LA;Kinney, TR
通讯作者：
Kinney, TR
影响因子：
2.8
作者：
COTTRELL, DB;FRINGS, CS
通讯作者：
FRINGS, CS
DOI：
10.1038/modpathol.2016.58
发表时间：
2016-07
期刊：
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
影响因子：
--
作者：
Barisoni L;Troost JP;Nast C;Bagnasco S;Avila-Casado C;Hodgin J;Palmer M;Rosenberg A;Gasim A;Liensziewski C;Merlino L;Chien HP;Chang A;Meehan SM;Gaut J;Song P;Holzman L;Gibson D;Kretzler M;Gillespie BW;Hewitt SM
通讯作者：
Hewitt SM
影响因子：
3.7
作者：
Chang JH;Paik SY;Mao L;Eisner W;Flannery PJ;Wang L;Tang Y;Mattocks N;Hadjadj S;Goujon JM;Ruiz P;Gurley SB;Spurney RF
通讯作者：
Spurney RF
影响因子：
13.6
作者：
Bartolucci, Pablo;Habibi, Anoosha;Audard, Vincent
通讯作者：
Audard, Vincent