Virulence and immunogenicity in experimental animals of Bacillus anthracis strains harbouring or lacking 110 MDa and 60 MDa plasmids.
Virulence and immunogenicity in experimental animals of Bacillus anthracis strains harbouring or lacking 110 MDa and 60 MDa plasmids.
复制标题
携带或缺乏 110 MDa 和 60 MDa 质粒的炭疽芽孢杆菌菌株在实验动物中的毒力和免疫原性。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
N. Terakado
中科院分区：
文献类型：
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作者：
I. Uchida;K. Hashimoto;N. Terakado
A comparative study was made of the virulence and immunogenicity in mice or guinea pigs of Bacillus anthracis strains harbouring 110 MDa and/or 60 MDa plasmids. Strains cured of the 110 MDa or the 60 MDa plasmid were more than 100-fold less virulent to mice than were the parental strains harbouring these plasmids. Guinea-pigs immunized with plasmid-free derivatives of the non-encapsulated vaccine strain 34F2 showed no resistance to challenge with strain 17JB, which harbours both 110 MDa and 60 MDa plasmids, suggesting that the derivative strains had lost their immunizing ability against anthrax.
