Evaluation of Visual Quality in Patients With Fuchs Endothelial Corneal Dystrophy
Evaluation of Visual Quality in Patients With Fuchs Endothelial Corneal Dystrophy
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DOI：
10.1097/ico.0000000000000994
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发表时间：
2016-11-01
期刊：
影响因子：
2.8
通讯作者：
Nishida, Kohji
中科院分区：
文献类型：
--
作者：
Oie, Yoshinori;Watanabe, Shinya;Nishida, Kohji
Fuchs内皮性角膜营养不良是一种以细胞外基质沉积、后弹力膜增厚、角膜内皮细胞进行性丢失为特征的双侧角膜内皮营养不良。进行性内皮细胞丢失导致角膜水肿，损害视功能。在患有FECD的眼睛中，角膜水肿始于中央角膜，并扩展到外围。FECD是许多国家角膜移植最常见的营养不良原因。一些患有FECD的患者报告说，尽管没有角膜水肿，但仍有视觉不适。眼内前向光散射损害患者的视觉质量(QOV)，与FECD相关的角膜点滴可能会引起眼内光散射和眩光，即使没有水肿，这也可能非常虚弱。我们最近调查了轻度FECD患者角膜滴眼液的严重程度对QOV的影响。结果表明，角膜滴眼液增加了前向光散射，对轻度FECD患者的QOV产生了负面影响，但无严重角膜水肿。因此，角膜滴眼液的定量将有助于确定轻度FECD的手术指征。这篇综述讨论了FECD患者的QOV。
Fuchs endothelial corneal dystrophy (FECD) is a bilateral corneal endothelial dystrophy characterized by the deposition of extracellular matrix (guttae), thickening of Descemet membrane, and progressive loss of corneal endothelial cells. Progressive endothelial cellular loss leads to corneal edema and impairs visual function. In eyes with FECD, corneal edema begins in the central cornea and expands into the periphery. FECD is the most common dystrophic reason for corneal transplantation in many countries. Some patients with FECD report visual discomfort despite the absence of corneal edema. Intraocular forward light scatter impairs patients' quality of vision (QOV), and corneal guttae associated with FECD may cause intraocular light scatter and glare, which can be extremely debilitating despite the absence of edema. We recently investigated the effect of the severity of corneal guttae on QOV in patients with mild FECD. It was shown that corneal guttae increased forward light scatter that negatively affected QOV in eyes with mild FECD without severe corneal edema. Therefore, quantification of corneal guttae would be useful to determine surgical indications for eyes with mild FECD. This review discusses QOV in patients with FECD.