MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain
MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain
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DOI：
10.1002/mrm.10511
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发表时间：
2003-07-01
影响因子：
3.3
通讯作者：
Frank, JA
中科院分区：
文献类型：
--
作者：
Bulte, JWM;Ben-Hur, T;Frank, JA
干细胞移植正在被探索作为治疗脱髓鞘疾病的新范式。将磁标记的多电位神经前体细胞移植到急性实验性变应性脑脊髓炎（EAE）大鼠脑室内，获得体外高分辨率（显微）MR图像。活细胞向心室周围白质结构的迁移模式可以很容易地看到，与相应的组织病理学有很好的相关性。目前的结果证实，MR细胞跟踪可用于指导成功移植方案的发展。(C) 2003 Wiley-Liss, Inc。
Stem cell transplantation is being explored as a new paradigm for the treatment of demyelinating diseases. Magnetically labeled multipotential neural precursor cells were transplanted into the ventricles of rats with acute experimental allergic encephalomyelitis (EAE) and high-resolution (microscopic) MR images were obtained ex vivo. Migration patterns of live cells into periventricular white matter structures could be easily visualized, with a good correlation of the corresponding histopathology. The present results confirm that MR cell tracking can be used to guide the development of successful transplantation protocols. (C) 2003 Wiley-Liss, Inc.