Pattern of Lymph Node Micrometastasis and Prognosis of Patients with Colorectal Cancer
Pattern of Lymph Node Micrometastasis and Prognosis of Patients with Colorectal Cancer
复制标题
结直肠癌患者淋巴结微转移规律及预后
DOI：
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发表时间：
2001
影响因子：
3.7
通讯作者：
S. Kitano
中科院分区：
文献类型：
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作者：
K. Yasuda;Y. Adachi;N. Shiraishi;K. Yamaguchi;Y. Hirabayashi;S. Kitano
摘要背景：对结直肠癌患者淋巴结微转移的研究忽略了淋巴结微转移的数量和水平的预后意义。本研究的目的是阐明淋巴结微转移状态在组织学淋巴结阴性结直肠癌中的预后意义。
研究方法：我们用抗细胞角蛋白抗体CAM 5.2的免疫组化方法检测了42例（12例复发和30例非复发）经组织学确诊的Dukes' B结直肠癌患者的1013个淋巴结。5个连续的6 μm切片用于免疫组织化学染色。比较复发组和非复发组的频率、肿瘤细胞类型、淋巴结微转移的数量和水平。
结果如下：复发组淋巴结微转移率为16%（59/373），无复发组为12%（77/640），复发组为92%（11/12），无复发组为70%（21/30）。复发组和非复发组转移淋巴结中的肿瘤细胞类型相似。复发组中4个或以上淋巴结的微转移发生率高于非复发组（58% vs. 20%，P < .05），复发组中N2以上淋巴结的微转移发生率高于非复发组（92% vs. 47%，P < .01）。
结论：Dukes' B期结直肠癌术后复发与淋巴结微转移的数量和水平显著相关。该参数是组织学淋巴结阴性结直肠癌的一个有用的预后指标，并有助于计划辅助化疗。
AbstractBackground: Studies of lymph node micrometastases in patients with colorectal cancer have ignored the prognostic significance of the number and level of lymph node micrometastases. The aim of this study was to clarify the prognostic significance of the status of lymph node micrometastases in histologically node-negative colorectal cancer.
Methods: We used immunohistochemistry with anti-cytokeratin antibody CAM5.2 to examine 1013 lymph nodes in 42 patients (12 recurrent and 30 nonrecurrent) with histologically determined Dukes’ B colorectal cancer. Five serial 6-μm sections were used for immunohistochemical staining. The frequency, tumor cell pattern, and number and level of lymph node micrometastases were compared between the recurrent and nonrecurrent groups.
Results: Micrometastasis was confirmed in 16% (59/373) of lymph nodes in the recurrent group and 12% (77/640) of lymph nodes in the nonrecurrent group, and the frequency of lymph node micrometastases was 92% (11/12) in the recurrent group and 70% (21/30) in the nonrecurrent group. The tumor cell pattern in the metastatic lymph nodes was similar in the recurrent and nonrecurrent groups. Micrometastasis in four or more lymph nodes occurred more frequently in the recurrent group than in the nonrecurrent group (58% vs. 20%, P < .05), and micrometastasis to N2 or higher nodes occurred more frequently in the recurrent group than in the nonrecurrent group (92% vs. 47%, P < .01).
Conclusions: The number and level of positive micrometastatic lymph nodes was significantly correlated with postoperative recurrence of histologically determined Dukes’ B colorectal cancer. This parameter is a useful prognostic indicator in histologically node-negative colorectal cancer and is helpful in planning adjuvant chemotherapy.
DOI：
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发表时间：
1985-03
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
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作者：
D. Cooper;A. Schermer;T. Sun
通讯作者：
D. Cooper;A. Schermer;T. Sun