Effect of topical ropivacaine on the response to endotracheal tube during emergence from general anesthesia: a prospective randomized double-blind controlled study
Effect of topical ropivacaine on the response to endotracheal tube during emergence from general anesthesia: a prospective randomized double-blind controlled study
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局部罗哌卡因对全身麻醉苏醒期间气管插管反应的影响：一项前瞻性随机双盲对照研究。
DOI：
10.1186/s12871-018-0601-x
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发表时间：
2018-09-27
影响因子：
2.2
通讯作者：
Liu, Xuesheng
中科院分区：
文献类型：
--
作者：
Fang, Panpan;Zong, Zhijun;Liu, Xuesheng
背景：呼吸道反射如咳嗽是常见的，并伴有严重的血流动力学波动。这一前瞻性双盲随机对照试验测试的假设，局部罗哌卡因可能会减少拔管反应和术后咽喉痛。方法：54例接受甲状腺切除术的患者被随机分为两组。R组采用0.75%罗哌卡因，将罗哌卡因喷洒于气管粘膜、会厌、舌根、声门等处，达到均匀表面麻醉。对照组给予等量生理盐水。结果：R组拔管时咳嗽发生率（34.62%vs.76.92%，P = 0.002）明显低于C组（P <0.01）。术后12 h R组咽痛视力评分低于C组（2.00 vs.3.50，P = 0.040）。结论：气管插管前0.75%罗哌卡因表面麻醉可明显减少拔管期咳嗽的发生。同时减少血流动力学波动和术后咽喉疼痛，不影响患者恢复。
Background: The airway reflex such as cough is common accompanied with severe fluctuations of hemodynamics during emergence. This prospective double-blind randomized controlled trial tested the hypothesis that topical ropivacaine may reduce extubation response and postoperative sore throat.Methods: Fifty-four patients undergoing thyroidectomy were randomly assigned to two groups. The patients in Group R were received 0.75% ropivacaine, which was sprayed on the tracheal mucosa, epiglottis, tongue base, and glottis to achieve uniform surface anesthesia. As control, patients in Group C were received the same volume saline. The primiary outcome was the incidence and grade of cough during peri-extubation.Results: The incidence (34.62% vs. 76.92%, P = 0.002) of cough during extubation were lower in Group R compared to Group C. Meanwhile, the sore throat visual acuity score at 12 h after surgery was lower in Group R than that in Group C (2.00 vs. 3.50, P = 0.040).Conclusion: Topical anesthesia with 0.75% ropivacaine before intubation can significantly reduce the incidence of cough during peri-extubation. Meanwhile, it reduced hemodynamic fluctuations and postoperative throat pain without influence patients recovery.