An auditory Go/No-Go study of event-related potentials in children with fetal alcohol spectrum disorders.
An auditory Go/No-Go study of event-related potentials in children with fetal alcohol spectrum disorders.
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胎儿酒精谱系障碍儿童事件相关电位的听觉 Go/No-Go 研究。
DOI：
10.1109/iembs.2011.6090181
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Sorensen,HelgeBD
中科院分区：
文献类型：
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作者：
Steinmann,TobiasP;Andrew,ColinM;Thomsen,CarstenE;Kjær,TroelsW;Meintjes,ErnestaM;Molteno,ChristopherD;Jacobson,JosephB;Jacobson,SandraW;Sorensen,HelgeBD
在这项研究中，事件相关电位（ERPs）被用来研究产前酒精暴露对任务执行过程中发现的反应抑制的影响。记录两组平均年龄为12.8岁（11岁至14.7岁）的儿童在听觉Go/No Go任务期间的erp：一组被诊断为胎儿酒精综合征（FAS）或部分FAS (FAS/PFAS; n = 12)，另一组同龄的母亲在怀孕期间戒酒或少量饮酒的对照组（n = 11）。孩子们被要求在听到“Go”刺激时按下按钮，而在听到“No Go”刺激时不按按钮。任务表现的准确性在两组之间没有差异，但在ERP组件：P2， N2和P3中观察到差异。两组围棋试验的P2振幅均较大。FAS/PFAS组对Go试验的N2反应较慢，表明刺激的早期分类效率较低。P3在两组中均比No-Go表现出更大的振幅。该研究为通过erp识别FAS/PFAS受试者的抑制缺陷提供了新的证据。
In this study event-related potentials (ERPs) were used to investigate the effects of prenatal alcohol exposure on response inhibition identified during task performance. ERPs were recorded during a auditory Go/No Go task in two groups of children with mean age of 12.8 years (11 years to 14.7 years): one diagnosed with fetal alcohol syndrome (FAS) or partial FAS (FAS/PFAS; n = 12) and a control group of children of same age whose mothers abstained from alcohol or drank minimally during pregnancy (n = 11). The children were instructed to push a button in response to the Go stimulus and not to press the button when the No Go stimulus were heard. Task performance accuracy did not differ between the two groups, however differences were observed in the ERP components: P2, N2, and P3. The P2 amplitude were larger for Go trials in both groups. The FAS/PFAS group showed slower N2 response to Go trials, suggesting a less efficient early classification of the stimulus. P3 showed larger amplitudes to No-Go vs. Go in both groups. The study has provided new evidence for inhibition deficits in FAS/PFAS subjects identified by ERPs.