An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise
An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise
复制标题
DOI：
10.1038/s41598-019-48587-2
复制
发表时间：
2019-08
影响因子：
4.6
通讯作者：
A. K. Ziegler;A. Damgaard;A. Mackey;P. Schjerling;P. Magnusson;P. Magnusson;A. T. Olesen;M. Kjaer;C. Schéele
中科院分区：
文献类型：
--
作者：
A. K. Ziegler;A. Damgaard;A. Mackey;P. Schjerling;P. Magnusson;P. Magnusson;A. T. Olesen;M. Kjaer;C. Schéele
内脏脂肪组织是一种免疫原性组织，在肥胖期间通过激活促炎巨噬细胞而变得有害。在衰老过程中，慢性炎症的增加与内脏脂肪组织（VAT）质量成正比，并与发病率和死亡率上升有关。在这里，我们利用小鼠模型来研究瘦衰老小鼠内脏脂肪组织的炎症状态，并评估运动训练干预的效果。我们将成年小鼠（11个月，n = 21）和老年小鼠（23个月，n = 27）随机分为抗阻训练组（RT）、耐力训练组（ET）和久坐对照组(S)。引人注目的是，与成年小鼠相比，我们在老年小鼠中观察到一种抗炎表型，包括更高的M2巨噬细胞积累和IL-10表达。与此一致的是，与成年小鼠相比，老年小鼠的VAT质量更少，脂肪细胞更小。在两个年龄组中，运动训练增强了抗炎表型并增加了PGC1-α mRNA的表达。有趣的是，棕色脂肪组织标记UCP1在老年小鼠中略有升高，但在干预后保持不变。总之，在没有肥胖的情况下，内脏脂肪组织在衰老过程中具有明显的抗炎表型，这种表型通过运动进一步增强。
Visceral adipose tissue is an immunogenic tissue, which turns detrimental during obesity by activation of proinflammatory macrophages. During aging, chronic inflammation increases proportional to visceral adipose tissue (VAT) mass and associates with escalating morbidity and mortality. Here, we utilize a mouse model to investigate the inflammatory status of visceral adipose tissue in lean aging mice and assess the effects of exercise training interventions. We randomized adult (11 months; n = 21) and old (23 months; n = 27) mice to resistance training (RT) or endurance training (ET), or to a sedentary control group (S). Strikingly, we observed an anti-inflammatory phenotype in the old mice, consisting of higher accumulation of M2 macrophages and IL-10 expression, compared to the adult mice. In concordance, old mice also had less VAT mass and smaller adipocytes compared to adult mice. In both age groups, exercise training enhanced the anti-inflammatory phenotype and increased PGC1-α mRNA expression. Intriguingly, the brown adipose tissue marker UCP1 was modestly higher in old mice, while remained unchanged by the intervention. In conclusion, in the absence of obesity, visceral adipose tissue possesses a pronounced anti-inflammatory phenotype during aging which is further enhanced by exercise.