Choroidal thickness changes in obstructive sleep apnea syndrome: a systematic review and meta-analysis
Choroidal thickness changes in obstructive sleep apnea syndrome: a systematic review and meta-analysis
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阻塞性睡眠呼吸暂停综合征的脉络膜厚度变化：系统评价和荟萃分析
DOI：
10.1007/s11325-015-1306-8
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发表时间：
2016-03-01
影响因子：
2.5
通讯作者：
Huang, Wenyong
中科院分区：
文献类型：
--
作者：
He, Miao;Han, Xiao;Huang, Wenyong
阻塞性睡眠呼吸暂停综合征（OSAS）是一种常见的慢性疾病，与缺氧和内皮和血管功能障碍有关。许多研究通过光学相干断层扫描（OCT）分析了不同严重程度OSAS患者与正常受试者的脉络膜厚度测量值，但结果不一致。因此，我们进行了一项荟萃分析，以评估OCT测量的OSAS患者脉络膜厚度变化。相关研究通过PubMed、Embase、Web of Science和科克伦图书馆从成立到2015年8月的全面检索进行检索。对于连续性结局，采用随机效应模型计算加权均数差（WMD）和95%可信区间（CI），最终纳入7个病例对照研究，共784只眼（OSAS组558只眼，正常对照组226只眼）。结果显示，与正常对照组相比，黄斑中心凹下脉络膜厚度（SFCT）显著降低，合并WMD为-8.06（95% CI -15.72至-0.41），中度OSAS为-29.99（95% CI -52.40至-7.58），重度OSAS为-53.72（95% CI -88.95至-18.48）。OSAS患者颞侧至中心凹1 mm处和鼻侧至中心凹1 mm处的脉络膜厚度也显著低于正常对照组（WMD =-28.94，95%CI-43.78 ~-14.10和WMD =-20.90，95%CI-36.62 ~-5.18）。考虑到OCT的无创性，OCT可能是一个有用的工具，OSAS的严重程度分级。
Obstructive sleep apnea syndrome (OSAS) is a common chronic disorder associated with hypoxia and endothelial and vascular dysfunction. Many studies have analyzed choroidal thickness measurements in patients with different severities of OSAS versus normal subjects by optical coherence tomography (OCT), but the results have been inconsistent. Therefore, a meta-analysis was performed to evaluate the choroidal thickness changes in OSAS measured by OCT.Pertinent studies were retrieved by a comprehensive search of PubMed, Embase, Web of Science, and the Cochrane Library from inception to August 2015. For continuous outcomes, the weighted mean difference (WMD) and 95 % confidence interval (CI) were calculated by using a random effects model.Seven case-control studies were included in the final meta-analysis, containing a total of 784 eyes (558 in the OSAS group and 226 in normal controls). The results showed that subfoveal choroidal thickness (SFCT) was significantly reduced compared with normal controls, with pooled WMD -8.06 (95 % CI -15.72 to -0.41) for mild OSAS, -29.99 (95 % CI -52.40 to -7.58) for moderate OSAS, and -53.72 (95 % CI -88.95 to -18.48) for severe OSAS. Choroidal thickness at 1 mm temporal to the fovea and at 1 mm nasal to the fovea were also significantly lower than those in the normal controls (WMD = -28.94, 95 % CI -43.78 to -14.10 and WMD = -20.90, 95 % CI -36.62 to -5.18).This meta-analysis suggests that choroidal thickness was reduced in OSAS. Considering the non-invasive nature of OCT, OCT could be a useful tool for grading the severity of OSAS.