Comparing the interobserver reproducibility of different regions of interest on multi-parametric renal magnetic resonance imaging in healthy volunteers, patients with heart failure and renal transplant recipients
Comparing the interobserver reproducibility of different regions of interest on multi-parametric renal magnetic resonance imaging in healthy volunteers, patients with heart failure and renal transplant recipients
复制标题
DOI：
10.1007/s10334-019-00809-4
复制
发表时间：
2020-02-01
影响因子：
2.3
通讯作者：
Gillis, Keith A.
中科院分区：
文献类型：
--
作者：
Rankin, Alastair J.;Allwood-Spiers, Sarah;Gillis, Keith A.
目的使用市售软件评估多参数肾脏MRI上不同感兴趣区域（ROIs）的观察者间重现性。材料与方法健康志愿者（HV）、心力衰竭（HF）患者和肾移植受者（Tx）。进行定位扫描、T1标测和伪连续动脉自旋标记（pCASL）。HV和Tx还进行了扩散加权成像，以计算表观扩散系数（ADC）。对于T1、pCASL和ADC，绘制了全肾（WK）、皮质（Cx）、用户定义的代表性皮质（rep-Cx）和髓质的ROI。评估组内相关系数（ICC）和变异系数（CoV）。结果40例受试者（HV 10例，HF 10例，Tx 20例）。肾脏体积的ICC为0.97，CoV为6.5%。对于T1和ADC，WK、Cx和rep-Cx具有高度可重复性，ICC >= 0.76且CoV <5%。然而，皮质pCASL结果更多变（ICC > 0.86，但CoV高达14.2%）。虽然具有重现性，但WK值来自广泛的数据（ADC和pCASL的ROI标准差分别为平均值的17%至55%）。两组之间的肾脏体积不同（p < 0.001），而Tx组的平均皮质T1值大于HV组（p = 0.009）和HF组（p = 0.02）。Tx的髓T1值也高于HV（p = 0.03），而Tx的髓pCASL值显著低于HV和HF（两者均为p = 0.03）。讨论通过手动勾画定位器扫描计算的肾脏体积在观察者之间具有高度重现性，并在患者组之间检测到显著差异。对于T1、pCASL和ADC，Cx和rep-Cx ROI通常具有重现性，优于WK值。
Objective To assess interobserver reproducibility of different regions of interest (ROIs) on multi-parametric renal MRI using commercially available software. Materials and methods Healthy volunteers (HV), patients with heart failure (HF) and renal transplant recipients (Tx) were recruited. Localiser scans, T1 mapping and pseudo-continuous arterial spin labelling (pCASL) were performed. HV and Tx also underwent diffusion-weighted imaging to allow calculation of apparent diffusion coefficient (ADC). For T1, pCASL and ADC, ROIs were drawn for whole kidney (WK), cortex (Cx), user-defined representative cortex (rep-Cx) and medulla. Intraclass correlation coefficient (ICC) and coefficient of variation (CoV) were assessed. Results Forty participants were included (10 HV, 10 HF and 20 Tx). The ICC for renal volume was 0.97 and CoV 6.5%. For T1 and ADC, WK, Cx, and rep-Cx were highly reproducible with ICC >= 0.76 and CoV < 5%. However, cortical pCASL results were more variable (ICC > 0.86, but CoV up to 14.2%). While reproducible, WK values were derived from a wide spread of data (ROI standard deviation 17% to 55% of the mean value for ADC and pCASL, respectively). Renal volume differed between groups (p < 0.001), while mean cortical T1 values were greater in Tx compared to HV (p = 0.009) and HF (p = 0.02). Medullary T1 values were also higher in Tx than HV (p = 0.03), while medullary pCASL values were significantly lower in Tx compared to HV and HF (p = 0.03 for both). Discussion Kidney volume calculated by manually contouring a localiser scan was highly reproducible between observers and detected significant differences across patient groups. For T1, pCASL and ADC, Cx and rep-Cx ROIs are generally reproducible with advantages over WK values.