Pulmonary venous pressure increases during alveolar hypoxia in isolated lungs of newborn pigs.
Pulmonary venous pressure increases during alveolar hypoxia in isolated lungs of newborn pigs.
复制标题
新生猪离体肺肺泡缺氧时，肺静脉压升高。
DOI：
10.1152/jappl.1992.73.2.552
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Kaplowitz,MR
中科院分区：
文献类型：
--
作者：
Fike,CD;Kaplowitz,MR
本研究的目的是确定新生猪肺部肺泡缺氧期间肺静脉压是否升高。我们从 7 只 6-7 天大的新生猪身上分离出肺部并用血液进行灌注。我们将血流量保持在 50 ml.min-1.kg-1 恒定，并持续监测肺动脉和左心房压力。使用微穿刺技术，我们测量了用常氧（21% O2–69–74% N2–5–10% CO2）和低氧（90–95% N2–5–10% CO2）气体混合物充气期间直径为 10 至 60 微米的小静脉的压力。常氧期间 PO2 为 142 +/- 21 Torr，缺氧期间 PO2 为 20 +/- 4 Torr。在微穿刺期间，我们将肺部充气至 5 cmH2O 的恒定气道压力，并保持左心房压力大于气道压力（区域 3）。缺氧期间，肺动脉压增加 69 +/- 24%，小静脉压力增加 40 +/- 23%。这些结果与新生羔羊和雪貂获得的结果相似，但与新生兔子的结果不同。新生儿肺部缺氧血管收缩的部位取决于物种。
The purpose of this study was to determine whether pulmonary venous pressure increases during alveolar hypoxia in lungs of newborn pigs. We isolated and perfused with blood the lungs from seven newborn pigs, 6–7 days old. We maintained blood flow constant at 50 ml.min-1.kg-1 and continuously monitored pulmonary arterial and left atrial pressures. Using the micropuncture technique, we measured pressures in 10 to 60-microns-diam venules during inflation with normoxic (21% O2–69–74% N2–5–10% CO2) and hypoxic (90–95% N2–5–10% CO2) gas mixtures. PO2 was 142 +/- 21 Torr during normoxia and 20 +/- 4 Torr during hypoxia. During micropuncture we inflated the lungs to a constant airway pressure of 5 cmH2O and kept left atrial pressure greater than airway pressure (zone 3). During hypoxia, pulmonary arterial pressure increased by 69 +/- 24% and pressure in small venules increased by 40 +/- 23%. These results are similar to those obtained with newborn lambs and ferrets but differ from results with newborn rabbits. The site of hypoxic vasoconstriction in newborn lungs is species dependent.