Serum vaspin levels are positively associated with carotid atherosclerosis in a general population
Serum vaspin levels are positively associated with carotid atherosclerosis in a general population
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DOI：
10.1016/j.atherosclerosis.2013.12.040
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发表时间：
2014-03-01
期刊：
影响因子：
5.3
通讯作者：
Imaizumi, Tsutomu
中科院分区：
文献类型：
--
作者：
Esaki, Eishi;Adachi, Hisashi;Imaizumi, Tsutomu
目的：Vaspin 是一种新型脂肪细胞因子，具有潜在的胰岛素增敏特性。胰岛素抵抗（IR）在动脉粥样硬化的发生和进展中发挥着重要作用。然而，血清 vaspin 水平与动脉粥样硬化之间的关系仍不清楚。因此，我们研究了 vaspin 是否与颈动脉内膜中层厚度 (c-IMT) 相关。方法：从日本普通人群中获得了 201 名受试者（78 名男性和 123 名女性，年龄超过 40 岁）的空腹 vaspin 水平数据。我们获得了人体测量参数和血液化学成分，并计算了稳态模型评估-IR（HOMA-IR）指数。 C-IMT 通过 B 型超声检查测量。采用方差分析比较vaspin各参数的三分位数平均值，并通过多元逐步回归分析评估vaspin与IR和c-IMT的相关性。结果：单因素分析显示，vaspin水平与BMI、胰岛素、HOMA-IR指数、估计肾小球滤过率（eGFR）、c-IMT和高血压药物呈正相关。多元逐步回归分析显示 HOMA-IR 指数、c-IMT 和 eGFR 与 vaspin 显着且独立相关。我们以 c-IMT 作为因变量进行了多变量分析。年龄、高血压药物和 Vaspin 对 c-IMT 具有重要意义。此外，中介分析表明，vaspin 与 c-IMT 显着相关，与 IR 无关。结论：本研究不仅证实了之前的发现，即 vaspin 与 IR 呈正相关，而且还证明在普通人群中，血清 vaspin 水平与 c-IMT 呈正相关，与 IR 无关。我们的结果可能表明 vaspin 在人类动脉粥样硬化中的作用。 (C) 2014 Elsevier Ireland Ltd. 保留所有权利。
Objectives: Vaspin is a novel adipocytokine with potential insulin-sensitizing properties. Insulin resistance (IR) plays a role in the development and progression of atherosclerosis. However, the relationship between serum vaspin levels and atherosclerosis remains unknown. Therefore, we investigated whether vaspin was correlated with carotid intima-media thickness (c-IMT).Methods: Data for fasting vaspin levels of 201 subjects (78 men and 123 women aged over 40 years) were obtained from a general population in Japan. We obtained anthropometric parameters and blood chemistries, and calculated homeostasis model assessment-IR (HOMA-IR) index. C-IMT was measured by B-mode ultrasonography. The mean values of each parameter by tertiles of vaspin were compared with analysis of variance, and the associations of vaspin with IR and c-IMT were evaluated by multiple stepwise regression analysis.Results: Univariate analysis revealed that vaspin levels were positively correlated with BMI, insulin, HOMA-IR index, estimated glomerular filtration rate (eGFR), c-IMT and hypertensive medication. Multiple stepwise regression analysis revealed that HOMA-IR index, c-IMT and eGFR were significantly and independently associated with vaspin. We performed multivariate analyses with c-IMT as the dependent variable. Age, hypertensive medication and vaspin were significant for c-IMT. Moreover, a mediation analysis demonstrated that vaspin was significantly related to c-IMT, independently of IR.Conclusions: The present study not only confirmed the previous finding of the positive association of vaspin with IR but also demonstrated that serum vaspin level was positively associated with c-IMT, independently of IR in a general population. Our results may suggest a role of vaspin in atherosclerosis in humans. (C) 2014 Elsevier Ireland Ltd. All rights reserved.