Muscle MRI in Becker muscular dystrophy
Muscle MRI in Becker muscular dystrophy
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DOI：
10.1016/j.nmd.2012.05.015
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发表时间：
2012-10-01
影响因子：
2.8
通讯作者：
Ricci, Enzo
中科院分区：
文献类型：
--
作者：
Tasca, Giorgio;Iannaccone, Elisabetta;Ricci, Enzo
本研究旨在评估46例贝克肌营养不良症（BMD）患者的骨盆和下肢肌肉磁共振成像（MRI）扫描结果，这些患者根据疾病严重程度进行了细分，从临床无症状患者到已丧失行走能力的患者不等。我们在肌肉成像中发现了一种独特的模式，其特征是臀大肌、臀中肌、大收肌、股二头肌长头、半膜肌和股四头肌明显受累。这种模式在所有25例有症状的患者中是一致的。在21例无症状患者中的13例中，发现相同肌肉有较轻微的变化。其他8例无症状患者扫描结果正常。肌肉受累的严重程度与年龄显著相关。我们的研究结果表明，在贝克肌营养不良症中可以检测到一种独特的肌肉受累模式。早期识别一部分无症状患者的肌肉变化可能作为诊断检查中的一个辅助工具是有用的。（c）2012爱思唯尔有限公司。保留所有权利。
The aim of this study was to evaluate pelvis and lower limb muscle MRI scans of 46 patients affected by Becker muscular dystrophy (BMD), subdivided according to disease severity, ranging from clinically asymptomatic patients to patients who had lost ambulation.We found a distinct pattern on muscle imaging characterized by prominent involvement of the gluteus maximus and medius, adductor magnus, biceps femoris long head, semimembranosus and vasti. This pattern was consistent in all the 25 symptomatic patients. Milder changes in the same muscles were found in 13 of the 21 asymptomatic cases. The other 8 asymptomatic patients had a normal scan. The severity of muscle involvement was significantly correlated with age.Our results suggest that a distinct pattern of muscle involvement can be detected in BM D. The early identification of muscle changes in a proportion of asymptomatic patients may be useful as an additional tool in the diagnostic workup. (c) 2012 Elsevier B.V. All rights reserved.