Muscle expression of genes associated with inflammation, growth, and remodeling is strongly correlated in older adults with resistance training outcomes
Muscle expression of genes associated with inflammation, growth, and remodeling is strongly correlated in older adults with resistance training outcomes
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DOI：
10.1152/physiolgenomics.00056.2009
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发表时间：
2009-07-01
影响因子：
4.6
通讯作者：
Peterson, Charlotte A.
中科院分区：
文献类型：
--
作者：
Dennis, Richard A.;Zhu, Haiyan;Peterson, Charlotte A.
黄晓明，陈晓华，黄晓明，陈晓华，陈晓琳，陈晓华，杨晓波，陈晓华，陈晓琳，陈晓华，在老年人中，与炎症、生长和重塑相关的基因的肌肉表达与阻力训练的结果密切相关。PhysIOL基因组学38：169-175,2009。2009年5月12日首次出版；DOI：10.1152/Physiolgenomics.00056.2009。-一组健康的老年(68+/-6岁)成年人(n=8)参加了一项针对大腿肌肉的36节渐进阻力运动训练计划，以确定肌肉基因表达与肌肉大小和力量增长之间的关系。在一次急性运动后72小时和完成训练计划后72小时，从股外侧肌取活组织标本。训练增加了大腿肌肉的大小(7%)和力量，进行了三种练习：膝关节伸展(30%)、卷曲(28%)和腿部挤压(20%)。我们量化了18个编码因子的转录本，这些转录因子在炎症、生长和肌肉重塑中发挥作用，以前证明这些转录因子受衰老和急性运动的调节。伸展力量和肌肉大小的增加与基因表达显示出很高的显著相关性。这些增长与胰岛素样生长因子-1、基质金属蛋白酶-2及其抑制物TIMP1和睫状神经营养因子的基线mRNA水平密切相关(P=0.89)。此外，力量增长与训练后这些信使核糖核酸水平的变化呈负相关(P
Dennis RA, Zhu H, Kortebein PM, Bush HM, Harvey JF, Sullivan DH, Peterson CA. Muscle expression of genes associated with inflammation, growth, and remodeling is strongly correlated in older adults with resistance training outcomes. Physiol Genomics 38: 169-175, 2009. First published May 12, 2009; doi: 10.1152/physiolgenomics.00056.2009.-A group (n = 8) of healthy older (68 +/- 6 yr) adults participated in a 36-session progressive resistance exercise training program targeting the thigh muscles to determine the relationship between muscle gene expression and gains in muscle size and strength. Biopsies were obtained from the vastus lateralis at baseline 72 h after an acute bout of exercise and 72 h after completion of the training program. Training increased thigh muscle size (7%) and strength for the three exercises performed: knee extension (30%) and curl (28%) and leg press (20%). We quantified 18 transcripts encoding factors that function in inflammation, growth, and muscle remodeling that were demonstrated previously to be regulated by aging and acute exercise. The gain in extension strength and muscle size showed a high number of significant correlations with gene expression. These gains were most strongly correlated (P = 0.89) with the baseline mRNA levels for insulin-like growth factor-1, matrix metalloproteinase-2 and its inhibitor TIMP1, and ciliary neurotrophic factor. Moreover, strength gains were inversely correlated with the change in these mRNA levels after training (P