Id and development
Id and development
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DOI：
10.1038/sj.onc.1205090
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发表时间：
2001-12-20
期刊：
影响因子：
8
通讯作者：
Yokota, Y
中科院分区：
文献类型：
--
作者：
Yokota, Y
在发育过程中，很明显，从一个受精卵建立一个身体计划需要大量的细胞增殖和多样化，这两个过程，增殖和分化，必须适当协调。Id蛋白是碱性螺旋-环-螺旋转录因子的负调控因子，具有抑制分化和刺激增殖的能力，是研究发育调控机制的有用分子。在过去的几年里，我们的理解的Id蛋白的作用已经大大提高了详细的调查转基因动物。这些数据表明，Id蛋白在体内的功能与早期在细胞培养系统中的工作所揭示的功能相关。然而，意想不到的器官和细胞类型也被发现需要Id蛋白用于其正常发育。本文综述了Id蛋白在体内功能研究的进展。讨论的主题包括神经发生、自然杀伤细胞发育、淋巴器官发生、乳腺发育和精子发生。
During development, it is obvious that enormous multiplication and diversification of cells is required to build a body plan from a single fertilized egg and that these two processes, proliferation and differentiation, must be coordinated properly. Id proteins, negative regulators of basic helix -loop - helix transcription factors, possess the ability to inhibit differentiation and to stimulate proliferation, and are useful molecules for investigating the mechanisms regulating development. In the past few years, our understanding of the roles of Id proteins has been substantially enhanced by the detailed investigation of genetically modified animals. The data have indicated that the functions of Id proteins in vivo are functionally related to those revealed by earlier work in cell culture systems. However, unexpected organs and cell types have also been found to require Id proteins for their normal development. This review looks at the advances made in our understanding of the in vivo functions of Id proteins. The topics discussed include neurogenesis, natural killer cell development, lymphoid organogenesis, mammary gland development and spermatogenesis.