Dry Eye Disease as an Inflammatory Disorder
Dry Eye Disease as an Inflammatory Disorder
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DOI：
10.3109/09273941003721926
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发表时间：
2010-08-01
影响因子：
3.3
通讯作者：
Corell, Alfredo
中科院分区：
文献类型：
--
作者：
Calonge, Margarita;Enriquez-de-Salamanca, Amalia;Corell, Alfredo
目的：干眼症（DED）是一种多因素起源的泪腺功能单位的普遍炎性病症，其导致慢性眼表疾病、视觉质量受损和广泛的并发症，最终导致生活质量降低。它仍然是一个令人沮丧的疾病，因为目前缺乏的疗法，可以扭转，或至少停止，其progress.Methods：一个全面的文献调查的英文书面科学出版物上的作用，炎症DED.Results：新的调查表明，慢性炎症反应在人类DED的发病机制中起着关键作用。此外，炎症分子与临床数据之间的相关性表明，炎症可能是某些临床症状和体征的原因。结论：阐明其病理生理学的研究工作正在使人们更好地了解DED，这表明除了许多其他因素之外，炎症也发挥着相关作用。
Purpose: Dry eye disease (DED) is a prevalent inflammatory disorder of the lacrimal functional unit of multifactorial origin leading to chronic ocular surface disease, impaired quality of vision, and a wide range of complications, eventually causing a reduction in quality of life. It still is a frustrating disease because of the present scarcity of therapies that can reverse, or at least stop, its progression.Methods: A comprehensive literature survey of English-written scientific publications on the role of inflammation in DED.Results: New investigations have demonstrated that a chronic inflammatory response plays a key role in the pathogenesis of human DED. Additionally, correlations between inflammatory molecules and clinical data suggest that inflammation can be responsible for some of the clinical symptoms and signs.Conclusions: Research efforts to clarify its pathophysiology are leading to a better understanding of DED, demonstrating that inflammation, in addition to many other factors, plays a relevant role.