Modulation of Host miRNAs by Intracellular Bacterial Pathogens.
Modulation of Host miRNAs by Intracellular Bacterial Pathogens.
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DOI：
10.3389/fcimb.2016.00079
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发表时间：
2016
影响因子：
5.7
通讯作者：
Dhandayuthapani S
中科院分区：
文献类型：
--
作者：
Das K;Garnica O;Dhandayuthapani S
MicroRNAs(MiRNAs)是一种在转录后水平上调节病毒和真核生物蛋白质编码基因表达的非编码短小RNA。受miRNAs调控的真核基因包括其产物对细胞增殖、代谢途径、免疫反应和发育等生物学过程至关重要的基因。现在越来越多的人认识到，调节与生物过程相关的miRNAs是细菌病原体在宿主细胞内生存所采用的策略之一。在这篇综述中，我们对兼性细胞内细菌病原体在宿主细胞中改变miRNAs的最新发现进行了综述。此外，我们还讨论了改变的miRNAs如何帮助这些病原体在细胞内环境中生存。
MicroRNAs (miRNAs) are short non-coding RNAs that regulate the expression of protein coding genes of viruses and eukaryotes at the post-transcriptional level. The eukaryotic genes regulated by miRNAs include those whose products are critical for biological processes such as cell proliferation, metabolic pathways, immune response, and development. It is now increasingly recognized that modulation of miRNAs associated with biological processes is one of the strategies adopted by bacterial pathogens to survive inside host cells. In this review, we present an overview of the recent findings on alterations of miRNAs in the host cells by facultative intracellular bacterial pathogens. In addition, we discuss how the altered miRNAs help in the survival of these pathogens in the intracellular environment.