Developmental Aspects of Spinal Locomotor Function: Insights from Using the in vitro Mouse Spinal Cord Preparation
Developmental Aspects of Spinal Locomotor Function: Insights from Using the in vitro Mouse Spinal Cord Preparation
复制标题
脊髓运动功能的发育方面：使用体外小鼠脊髓制备的见解
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
P. Whelan
中科院分区：
文献类型：
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作者：
P. Whelan
在过去的五年里，我们对运动中枢模式发生器（CPG）的位置、功能以及最近的组织结构的理解取得了快速进展。在哺乳动物中，新生大鼠的使用在很大程度上促成了这些进展。此外，体外小鼠脊髓制备的使用变得越来越普遍，部分原因是使用遗传方法研究运动功能的潜力。虽然诱人，但有必要抵制先验假设，即大鼠和小鼠的脊髓CPG组织是相同的。本综述将描述小鼠从胚胎第12天到出生后第14天的运动样行为的发展。虽然我们的知识仍有许多差距，但与大鼠相比，体外小鼠似乎遵循定性相似的运动发育过程。本次审查的重点是使用或潜在使用的小鼠作为补充现有的数据，使用新生大鼠制备。
Over the last five years, rapid advances have been made in our understanding of the location, function, and recently, organization of the central pattern generator (CPG) for locomotion. In the mammal, the use of the neonatal rat has largely contributed to these advances. Additionally, the use of the in vitro mouse spinal cord preparation is becoming more common, catalysed in part by the potential for the use of genetic approaches to study locomotor function. Although tempting, it is necessary to resist the a priori assumption that the organization of the spinal CPG is identical in the rat and mouse. This review will describe the development of locomotor‐like behaviour in the mouse from embryonic day 12 to postnatal day 14. While there are still many gaps in our knowledge, compared with the rat, the in vitro mouse appears to follow a qualitatively similar course of locomotor development. The emphasis in this review is the use or potential use of the mouse as a complement to existing data using the neonatal rat preparation.
成年哺乳动物腰骶脊髓在没有脊髓上输入的情况下执行和获得改善运动的潜力。
影响因子：
4.2
作者：
Edgerton,VR;Roy,RR;Hodgson,JA;Prober,RJ;deGuzman,CP;deLeon,R
通讯作者：
deLeon,R
影响因子：
2.5
作者：
Whelan, P;Bonnot, A;O'Donovan, MJ
通讯作者：
O'Donovan, MJ